Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis. (Q40100660)

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2 January 2020

title

Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis (English)

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2 January 2020

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7

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2 January 2020

author name string

Stephan Singer

1

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2 January 2020

Volker Ehemann

2

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2 January 2020

Antje Brauckhoff

3

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2 January 2020

Martina Keith

4

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2 January 2020

Sebastian Vreden

5

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2 January 2020

Peter Schirmacher

6

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2 January 2020

language of work or name

English

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publication date

1 September 2007

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2 January 2020

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2 January 2020

volume

46

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issue

3

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2 January 2020

page(s)

759-768

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Role for protein phosphatases in the cell-cycle-regulated phosphorylation of stathmin

2 January 2020

cites work

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Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression

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Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56 T-cell large granular lymphocyte leukemia

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Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.

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Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53.

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Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma.

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Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells

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Determination of cell number in monolayer cultures

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Flow cytometric detection of spontaneous apoptosis in human breast cancer using the TUNEL-technique

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Identification of methionine-containing tryptic peptides of unstable beta-tubulin separated by reverse-phase high-performance liquid chromatography

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Immunohistochemical detection of oncoprotein 18 (Op18) in malignant lymphomas

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p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines

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Involvement of OP18 in cell proliferation

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Stathmin is expressed by the proliferating hepatocytes during liver regeneration

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Distinct and sequential upregulation of genes regulating cell growth and cell cycle progression during hepatic ischemia-reperfusion injury

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The stathmin family -- molecular and biological characterization of novel mammalian proteins expressed in the nervous system.

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Liver Gene Expression Signature of Mild Fibrosis in Patients With Chronic Hepatitis C

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STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells

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The protein kinase C inhibitor H7 blocks phosphorylation of stathmin during TPA-induced growth inhibition of human pre-B leukemia REH6 cells

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

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p21/CDKN1A mediates negative regulation of transcription by p53.

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7 January 2021

Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene

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7 January 2021

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

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7 January 2021

E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress

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7 January 2021

Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade--results of an explorative CGH meta-analysis

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7 January 2021