A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis (Q40092320)

6 October 2017

A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis (English)

1 reference

6 October 2017

6

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12 June 2020

Xiang Ye

3

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12 June 2020

author name string

Michael T Jacobsen

1

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12 June 2020

Mark E Petersen

2

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12 June 2020

Mathieu Galibert

4

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12 June 2020

George H Lorimer

5

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12 June 2020

Michael S Kay

7

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12 June 2020

language of work or name

English

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publication date

17 August 2016

1 reference

Journal of the American Chemical Society

6 October 2017

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12 June 2020

volume

138

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12 June 2020

issue

36

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12 June 2020

page(s)

11775-11782

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The road to the synthesis of "difficult peptides".

12 June 2020

cites work

1 reference

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Solid phase protein chemical synthesis

15 June 2018

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Critical evaluation and rate constants of chemoselective ligation reactions for stoichiometric conjugations in water

15 June 2018

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Peptide o-aminoanilides as crypto-thioesters for protein chemical synthesis

15 June 2018

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Chemical synthesis and biophysical applications of membrane proteins

15 June 2018

1 reference

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Serine/threonine ligation for the chemical synthesis of proteins

15 June 2018

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Recent extensions to native chemical ligation for the chemical synthesis of peptides and proteins.

15 June 2018

1 reference

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15 June 2018

Mirror image proteins

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Formation and structures of GroEL:GroES2 chaperonin footballs, the protein-folding functional form

15 June 2018

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Synthesis and folding of a mirror-image enzyme reveals ambidextrous chaperone activity

15 June 2018

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Total chemical synthesis of biologically active fluorescent dye-labeled Ts1 toxin

15 June 2018

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Expedient total synthesis of small to medium-sized membrane proteins via Fmoc chemistry.

15 June 2018

1 reference

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Improved chemical synthesis of hydrophobic Aβ peptides using addition of C-terminal lysines later removed by carboxypeptidase B.

15 June 2018

1 reference

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Erythropoietin derived by chemical synthesis

15 June 2018

1 reference

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The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last.

15 June 2018

1 reference

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PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins

15 June 2018

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Non-enzymatic synthesis of ubiquitin chains: where chemistry makes a difference

15 June 2018

1 reference

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Synthetic cysteine surrogates used in native chemical ligation

15 June 2018

1 reference

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At last: erythropoietin as a single glycoform

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Chemistry and Biology of the Ubiquitin Signal

15 June 2018

1 reference

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Rational development of a strategy for modifying the aggregatibility of proteins

15 June 2018

1 reference

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Toward homogeneous erythropoietin: non-NCL-based chemical synthesis of the Gln78-Arg166 glycopeptide domain

15 June 2018

1 reference

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Total chemical synthesis of proteins

15 June 2018

1 reference

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Chemoselective ligation and modification strategies for peptides and proteins.

15 June 2018

1 reference

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Chemical synthesis and semisynthesis of membrane proteins

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Modular total chemical synthesis of a human immunodeficiency virus type 1 protease

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Total synthesis by modern chemical ligation methods and high resolution (1.1 A) X-ray structure of ribonuclease A

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Synthetic erythropoietic proteins: tuning biological performance by site-specific polymer attachment

15 June 2018

1 reference

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Synthesis of the C-terminal region of opioid receptor like 1 in an SDS micelle by the native chemical ligation: effect of thiol additive and SDS concentration on ligation efficiency

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein

15 June 2018

1 reference

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Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry

15 June 2018

1 reference

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Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution

15 June 2018

1 reference

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Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain

15 June 2018

1 reference

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The structure of a centrosymmetric protein crystal

15 June 2018

1 reference

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Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes

15 June 2018

1 reference

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Synthesis of proteins by native chemical ligation

15 June 2018

1 reference

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δ-Conotoxins synthesized using an acid-cleavable solubility tag approach reveal key structural determinants for NaV subtype selectivity.

15 June 2018

1 reference

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New chemistries for chemoselective peptide ligations and the total synthesis of proteins

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Patchwork protein chemistry: a practitioner's treatise on the advances in synthetic peptide stitchery

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Rethinking amide bond synthesis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Robust Chemical Synthesis of Membrane Proteins through a General Method of Removable Backbone Modification.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Chemical synthesis of proteins using peptide hydrazides as thioester surrogates.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Bringing the science of proteins into the realm of organic chemistry: total chemical synthesis of SEP (synthetic erythropoiesis protein).

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Chemical synthesis of a masked analogue of the fish antifreeze potentiating protein (AFPP).

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Cleavable trifunctional biotin reagents for protein labelling, capture and release.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Synthesis of autophagosomal marker protein LC3-II under detergent-free conditions

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Total Chemical Synthesis of Di‐ubiquitin Chains

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Toward the total chemical synthesis of the cancer protein NY-ESO-1.

20 August 2018

1 reference

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Design and synthesis of a homogeneous erythropoietin analogue with two human complex-type sialyloligosaccharides: combined use of chemical and bacterial protein expression methods.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Highly efficient and chemoselective peptide ubiquitylation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Use of a temporary "solubilizing" peptide tag for the Fmoc solid-phase synthesis of human insulin glargine via use of regioselective disulfide bond formation.

20 August 2018

1 reference

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Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-thioester building blocks.

20 August 2018

1 reference

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Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

A one-pot total synthesis of crambin

20 August 2018

1 reference

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Synthesis of peptides and proteins without cysteine residues by native chemical ligation combined with desulfurization

20 August 2018

1 reference

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Covalent capture: a new tool for the purification of synthetic and recombinant polypeptides

20 August 2018

1 reference

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Total chemical synthesis of a D-enzyme: the enantiomers of HIV-1 protease show reciprocal chiral substrate specificity [corrected]

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Linear versus branched poly-lysine/arginine as polarity enhancer tags

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094862

Basis of Substrate Binding by the Chaperonin GroEL†

2 December 2018

1 reference

12 December 2020

Full orthogonality between Dde and Fmoc: the direct synthesis of PNA--peptide conjugates

1 reference

12 December 2020

Chemical synthesis of 10 kDa chaperonin Biological activity suggests chaperonins do not require other molecular chaperones

1 reference

12 December 2020

Total Chemical Synthesis of an Integral Membrane Enzyme: Diacylglycerol Kinase from Escherichia coli

1 reference

12 December 2020

Protein chemical synthesis by ligation of peptide hydrazides

1 reference

12 December 2020

Synthesis of cyclic peptides and cyclic proteins via ligation of peptide hydrazides

1 reference

12 December 2020

Chemical synthesis of an erythropoietin glycoform containing a complex-type disialyloligosaccharide

1 reference

12 December 2020

Flexibility of GroES mobile loop is required for efficient chaperonin function

1 reference

12 December 2020

Convergent chemical synthesis of proteins by ligation of peptide hydrazides

1 reference

12 December 2020

Selective, on-resin N-methylation of peptide N-trifluoroacetamides

1 reference

12 December 2020

Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues

1 reference

12 December 2020

N,O‐bisFmoc derivatives of N‐(2‐hydroxy‐4‐methoxybenzyl)‐amino acids: Useful intermediates in peptide synthesis

1 reference

12 December 2020

Identifiers

DOI

10.1021/JACS.6B05719

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532670 AND SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27532670 AND SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

27532670

1 reference