Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival. (Q40066296)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28873507 AND SRC:MED&resulttype=core&format=json

29 March 2020

title

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival (English)

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29 March 2020

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1

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29 March 2020

Jenifer Coburn

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29 March 2020

author name string

Yi-Pin Lin

2

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29 March 2020

Julie R Kessler

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29 March 2020

Hiromi Sato

4

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29 March 2020

John M Leong

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29 March 2020

language of work or name

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26 September 2017

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29 March 2020

published in

Cellular Microbiology

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29 March 2020

volume

19

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29 March 2020

issue

12

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In Vivo Imaging Demonstrates That Borrelia burgdorferi ospC Is Uniquely Expressed Temporally and Spatially throughout Experimental Infection

29 March 2020

cites work

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Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex

30 August 2018

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Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

30 August 2018

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Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages.

30 August 2018

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A short-term Borrelia burgdorferi infection model identifies tissue tropisms and bloodstream survival conferred by adhesion proteins

30 August 2018

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Crystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H

30 August 2018

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CspA from Borrelia burgdorferi inhibits the terminal complement pathway

30 August 2018

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ErpC, a member of the complement regulator-acquiring family of surface proteins fromBorrelia burgdorferi, possesses an architecture previously unseen in this protein family

30 August 2018

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30 August 2018

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Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance ofBorrelia burgdorferi

30 August 2018

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Allelic Variation of the Lyme Disease Spirochete Adhesin DbpA Influences Spirochetal Binding to Decorin, Dermatan Sulfate, and Mammalian Cells

30 August 2018

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Multiplex PCR as a tool for validating plasmid content of Borrelia burgdorferi

30 August 2018

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30 August 2018

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Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi

30 August 2018

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Repeated domains of leptospira immunoglobulin-like proteins interact with elastin and tropoelastin

30 August 2018

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CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi

30 August 2018

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In vitro CpG methylation increases the transformation efficiency of Borrelia burgdorferi strains harboring the endogenous linear plasmid lp56

30 August 2018

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Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.

30 August 2018

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Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection

30 August 2018

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Reciprocal expression of ospA and ospC in single cells of Borrelia burgdorferi

30 August 2018

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Coordinated expression of Borrelia burgdorferi complement regulator-acquiring surface proteins during the Lyme disease spirochete's mammal-tick infection cycle

30 August 2018

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Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi

30 August 2018

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Antibody-mediated disease remission in the mouse model of lyme borreliosis

30 August 2018

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Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection

30 August 2018

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Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans

30 August 2018

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Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response.

30 August 2018

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30 August 2018

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30 August 2018

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Genetic Diversity among Borrelia Strains Determined by Single-Strand Conformation Polymorphism Analysis of the ospC Gene and Its Association with Invasiveness

30 August 2018

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30 August 2018

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Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs.

30 August 2018

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30 August 2018

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Disease severity in a murine model of lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strain

30 August 2018

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Genetic diversity of the outer surface protein C gene of southern Borrelia isolates and its possible epidemiological, clinical, and pathogenetic implications

30 August 2018

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Genetic analysis of the outer surface protein C gene of Lyme disease spirochaetes (Borrelia burgdorferi sensu lato) isolated from rodents in Taiwan.

30 August 2018

1 reference

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Quantitative detection of Borrelia burgdorferi in 2-millimeter skin samples of erythema migrans lesions: correlation of results with clinical and laboratory findings

30 August 2018

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Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background

30 August 2018

1 reference

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Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi

30 August 2018

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Impact of genotypic variation of Borrelia burgdorferi sensu stricto on kinetics of dissemination and severity of disease in C3H/HeJ mice

30 August 2018

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Lack of a role for iron in the Lyme disease pathogen

30 August 2018

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Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans

30 August 2018

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30 August 2018

Complement regulation

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Immunization with outer surface protein (Osp) A, but not OspC, provides cross-protection of mice challenged with North American isolates of Borrelia burgdorferi

30 August 2018

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Complement-mediated serum sensitivity among spirochetes that cause Lyme disease.

30 August 2018

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

30 August 2018

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Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC

30 August 2018

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Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi.

30 August 2018

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Borrelia burgdorferi infection and immunity in mice deficient in the fifth component of complement.

30 August 2018

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Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen

30 August 2018

1 reference

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Induction of an outer surface protein on Borrelia burgdorferi during tick feeding

30 August 2018

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Isolation and cultivation of Lyme disease spirochetes

30 August 2018

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The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor

30 August 2018

1 reference

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Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins

30 August 2018

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Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov., and group VS461 associated with Lyme borreliosis

30 August 2018

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Active immunization with pC protein ofBorrelia burgdorferi protects gerbils againstB. burgdorferi infection

30 August 2018

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Electrotransformation of the spirochete Borrelia burgdorferi

30 August 2018

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Crossref

https://api.crossref.org/works/10.1111/CMI.12786

Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis

21 January 2018

1 reference

12 December 2020

Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1

1 reference

12 December 2020

Immune evasion of Borrelia burgdorferi by acquisition of human complement regulators FHL-1/reconectin and Factor H

1 reference

12 December 2020

Comparison of findings for patients with Borrelia garinii and Borrelia afzelii isolated from cerebrospinal fluid

1 reference

12 December 2020

New Antibiotic Resistance Cassettes Suitable for Genetic Studies in <i>Borrelia burgdorferi</i>

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12 December 2020

Identifiers

DOI

10.1111/CMI.12786

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28873507 AND SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28873507 AND SRC:MED&resulttype=core&format=json

29 March 2020

PubMed publication ID

28873507

1 reference