Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses. (Q40041650)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8057485 AND SRC:MED&resulttype=core&format=json

24 October 2019

title

Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses (English)

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24 October 2019

1 reference

T Horimoto

1

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24 October 2019

K Nakayama

series ordinal

2

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24 October 2019

S P Smeekens

series ordinal

3

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24 October 2019

Y Kawaoka

series ordinal

4

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24 October 2019

language of work or name

English

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publication date

1 September 1994

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24 October 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8057485 AND SRC:MED&resulttype=core&format=json

24 October 2019

volume

68

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24 October 2019

issue

9

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24 October 2019

page(s)

6074-6078

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Legitimate and illegitimate cleavage of human immunodeficiency virus glycoproteins by furin

24 October 2019

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1 reference

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PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway

22 September 2017

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Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4

22 September 2017

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Importance of conserved amino acids at the cleavage site of the haemagglutinin of a virulent avian influenza A virus

22 September 2017

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22 September 2017

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Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus.

22 September 2017

1 reference

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PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE

22 September 2017

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Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus

22 September 2017

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22 September 2017

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Processing of protein precursors by a novel family of subtilisin-related mammalian endoproteases

22 September 2017

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A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells

22 September 2017

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Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

22 September 2017

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Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques

22 September 2017

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Influenza virus A pathogenicity: the pivotal role of hemagglutinin

22 September 2017

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22 September 2017

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22 September 2017

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Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells

22 September 2017

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Interplay between carbohydrate in the stalk and the length of the connecting peptide determines the cleavability of influenza virus hemagglutinin

22 September 2017

1 reference

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Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

22 September 2017

1 reference

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cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases

22 September 2017

1 reference

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Mammalian subtilisins: the long-sought dibasic processing endoproteases

22 September 2017

1 reference

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Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

22 September 2017

1 reference

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Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans

22 September 2017

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Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1.

22 September 2017

1 reference

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Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

22 September 2017

1 reference

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Cloning and Functional Expression of a Novel Endoprotease Involved in Prohormone Processing at Dibasic Sites1

22 September 2017

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The new enzymology of precursor processing endoproteases

22 September 2017

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Mammalian subtilisin-related proteinases in cleavage activation of the paramyxovirus fusion glycoprotein: superiority of furin/PACE to PC2 or PC1/PC3

22 September 2017

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Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

22 September 2017

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An endoprotease homologous to the blood clotting factor X as a determinant of viral tropism in chick embryo

22 September 2017

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Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion.

25 September 2017

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Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease

17 June 2018

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Processing protease for gp160 human immunodeficiency virus type I envelope glycoprotein precursor in human T4 lymphocytes. Purification and characterization.

17 June 2018

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Proteolytic cleavage of influenza virus hemagglutinins: primary structure of the connecting peptide between HA1 and HA2 determines proteolytic cleavability and pathogenicity of Avian influenza viruses

17 June 2018

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Mutations at the cleavage site of the hemagglutinin after the pathogenicity of influenza virus A/chick/Penn/83 (H5N2).

17 June 2018

1 reference

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Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells

17 June 2018

1 reference

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Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

17 June 2018

1 reference

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Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease

17 June 2018

1 reference

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Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R

17 June 2018

1 reference

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Location and character of the cellular enzyme that cleaves the hemagglutinin of a virulent avian influenza virus

17 June 2018

1 reference

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Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression

17 June 2018

1 reference

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Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line

17 June 2018

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Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis

17 June 2018

1 reference

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Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant

20 August 2018

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Changes in the antigenicity of the hemagglutinin molecule of H3 influenza virus at acidic pH.

20 August 2018

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Proteolytic cleavage by plasmin of the HA polypeptide of influenza virus: host cell activation of serum plasminogen

20 August 2018

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20 August 2018

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Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4

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12 December 2020

Isolation and characterization of a novel trypsin-like protease found in rat bronchiolar epithelial Clara cells. A possible activator of the viral fusion glycoprotein

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Role of Staphylococcus protease in the development of influenza pneumonia

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Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8057485 AND SRC:MED&resulttype=core&format=json

24 October 2019

PubMed publication ID

8057485

1 reference