Pharmacological analysis of human D1 AND D2 dopamine receptor missense variants (Q40022211)

16 September 2017

title

Pharmacological analysis of human D1 AND D2 dopamine receptor missense variants (English)

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16 September 2017

Munya A Al-Fulaij

1

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16 September 2017

Yong Ren

series ordinal

2

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16 September 2017

Martin Beinborn

series ordinal

3

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16 September 2017

Alan S Kopin

series ordinal

4

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16 September 2017

publication date

18 January 2008

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Journal of Molecular Neuroscience

16 September 2017

published in

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16 September 2017

volume

34

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16 September 2017

issue

3

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16 September 2017

page(s)

211-223

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Inverse agonism and the regulation of receptor number

16 September 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007/S12031-007-9030-X

Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery

21 January 2018

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Novel mutations of the endothelin B receptor gene in patients with Hirschsprung's disease and their characterization

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Pharmacological chaperone activity of SR49059 to functionally recover misfolded mutations of the vasopressin V1a receptor

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An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system

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Cloning of the cDNA and gene for a human D2 dopamine receptor

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A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants

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Inverse, protean, and ligand-selective agonism: matters of receptor conformation

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Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets

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Structure and function of dopamine receptors

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A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists

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Genetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinases

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Beta-adrenergic receptor polymorphism in human cardiovascular disease

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Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha

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Identification of amino acid determinants of dopamine 2 receptor synthetic agonist function

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A missense mutation in the seven-transmembrane domain of the human Ca2 receptor converts a negative allosteric modulator into a positive allosteric modulator

1 reference

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Structural change in dopamine D2 receptor gene in a patient with neuroleptic malignant syndrome

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Ligand function at constitutively active receptor mutants is affected by two distinct yet interacting mechanisms

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A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL).

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SCH23390 causes persistent antidopaminergic effects in vivo: evidence for longterm occupation of receptors

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SCH 23390—The first selective dopamine D-1 antagonist

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Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization

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Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation

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A structural polymorphism of human dopamine D2 receptor, D2(Ser311-->Cys).

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Gonadotropin-releasing hormone neuronal cell lines

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The molecular basis of nephrogenic diabetes insipidus

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Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells

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Dopamine receptors: from structure to function

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Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

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Differential efficacies of dopamine D1 receptor agonists for stimulating adenylyl cyclase in squirrel monkey and rat.

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Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein

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Functional analysis of the human D2 dopamine receptor missense variants

1 reference

12 December 2020

High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype

1 reference

12 December 2020

5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle

1 reference

12 December 2020

Inverse agonism at heptahelical receptors: concept, experimental approach and therapeutic potential

1 reference

12 December 2020

10.1007/S12031-007-9030-X

Identifiers

DOI

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Dimensions Publication ID

16 September 2017

1039517733

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