Cell-Penetrating Fragments of the Cdk5 Regulatory Subunit Are Protective in Models of Neurodegeneration (Q39948799)

15 September 2017

Cell-Penetrating Fragments of the Cdk5 Regulatory Subunit Are Protective in Models of Neurodegeneration (English)

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15 September 2017

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Jan Liman

1

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15 September 2017

Jochen H Weishaupt

series ordinal

2

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15 September 2017

Mathias Bähr

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3

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15 September 2017

Gunnar P H Dietz

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4

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15 September 2017

23 April 2010

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15 September 2017

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15 September 2017

3

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15 September 2017

4

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15 September 2017

1232-1240

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Creative Commons Attribution 4.0 International

15 September 2017

start time

23 April 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Application of a blood-brain-barrier-penetrating form of GDNF in a mouse model for Parkinson's disease

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Parkin attenuates manganese-induced dopaminergic cell death

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Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide

22 September 2017

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Intravenous TAT-GDNF is protective after focal cerebral ischemia in mice

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A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

22 September 2017

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22 September 2017

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Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

22 September 2017

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Neurotoxicity induces cleavage of p35 to p25 by calpain

22 September 2017

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Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

22 September 2017

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In vivo protein transduction: delivery of a biologically active protein into the mouse

22 September 2017

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Identification of functional domains in the neuronal Cdk5 activator protein

22 September 2017

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Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases

22 September 2017

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Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.

15 June 2018

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p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

20 August 2018

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Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease

20 August 2018

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Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

20 August 2018

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Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats

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20 August 2018

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A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5): modulation of cAMP-induced apoptosis in rat leukemia cells

20 August 2018

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Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

20 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390/PH3041232

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27713298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27713298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27713298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/PH3041232

1 reference

15 September 2017

1 reference

15 September 2017

PubMed publication ID

27713298

1 reference