Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors. (Q39884649)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19212341 AND SRC:MED&resulttype=core&format=json

21 January 2020

title

Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors (English)

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21 January 2020

3

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21 January 2020

Richard F. Kefford

5

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21 January 2020

Helen Rizos

6

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21 January 2020

author name string

Sebastian Haferkamp

1

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21 January 2020

Lyndee L Scurr

2

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21 January 2020

Monika Frausto

4

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language of work or name

English

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publication date

12 February 2009

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Journal of Investigative Dermatology

21 January 2020

published in

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21 January 2020

volume

129

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issue

8

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21 January 2020

page(s)

1983-1991

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Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging

21 January 2020

cites work

1 reference

7 January 2021

Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations

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7 January 2021

The signals and pathways activating cellular senescence

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7 January 2021

Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines

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7 January 2021

Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation

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7 January 2021

Oncogene-induced senescence as an initial barrier in lymphoma development

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

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Malignant melanoma: genetics and therapeutics in the genomic era.

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Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

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Tumour biology: senescence in premalignant tumours

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Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo

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7 January 2021

Distinct sets of genetic alterations in melanoma

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7 January 2021

Mutations of the BRAF gene in human cancer

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7 January 2021

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

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7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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7 January 2021

A Third-Generation Lentivirus Vector with a Conditional Packaging System

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7 January 2021

High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL

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7 January 2021

Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents

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7 January 2021

Detection of B-RAF and N-RAS mutations in human melanoma

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7 January 2021

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

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7 January 2021

Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

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7 January 2021

ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

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7 January 2021

Human melanocytes cultured from nevi and melanomas

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7 January 2021

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts

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7 January 2021

Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response

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7 January 2021

A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6

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7 January 2021

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

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7 January 2021

BRAF mutations are common somatic events in melanocytic nevi

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7 January 2021

The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development

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7 January 2021

Comment on “Absence of Senescence-Associated β-Galactosidase Activity in Human Melanocytic Nevi In Vivo”

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7 January 2021

BRAFE600-associated senescence-like cell cycle arrest of human naevi

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7 January 2021

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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7 January 2021

p19ARF links the tumour suppressor p53 to Ras

1 reference

7 January 2021

High frequency of BRAF mutations in nevi

1 reference

7 January 2021

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1 reference

7 January 2021

BRAF and NRAS mutations in melanoma and melanocytic nevi

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7 January 2021

Production and concentration of pseudotyped HIV-1-based gene transfer vectors

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7 January 2021

Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells.

1 reference

7 January 2021

The mammalian unfolded protein response

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7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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7 January 2021

The INK4a/ARF locus and melanoma

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7 January 2021

Ras, PI(3)K and mTOR signalling controls tumour cell growth

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7 January 2021

Deregulated Akt3 activity promotes development of malignant melanoma

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7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

7 January 2021

p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

1 reference

7 January 2021

BRAF mutation: a frequent event in benign, atypical, and malignant melanocytic lesions of the skin

1 reference

7 January 2021

The tumor-suppressive functions of the human INK4A locus

1 reference

7 January 2021

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

1 reference

7 January 2021

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1 reference

7 January 2021

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging

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7 January 2021

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

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7 January 2021

Identifiers

DOI

10.1038/JID.2009.5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19212341 AND SRC:MED&resulttype=core&format=json

release_zxbwfwm2rzaglobcy54xokfkku

21 January 2020

Fatcat ID

0 references

1 reference