Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition (Q39879677)

8 January 2018

title

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition (English)

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8 January 2018

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Guy A Rouleau

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Jean-François Schmouth

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Jean-François Schmouth

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Perrine Inquimbert

Perrine Inquimbert

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Jinwei Zhang

Jinwei Zhang

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Patrick A Dion

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Patrick A Dion

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Kristopher T Kahle

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Pascale Hince

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Pascale Hince

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Daniel Rochefort

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Daniel Rochefort

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Janet L Laganière

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Janet Laganière

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Rébecca Gaudet

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Rébecca Gaudet

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8 January 2018

Valérie Lavastre

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Valérie Lavastre

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Susana G Sotocinal

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Susana G Sotocinal

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Clifford J Woolf

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author name string

Alban Latremoliere

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Nick Andrews

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Takao Omura

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Geneviève Castonguay

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Josiane C S Mapplebeck

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JingJing Duan

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Catherine Ward

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Arjun R Khanna

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Jeffrey S Mogil

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publication date

29 March 2016

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8 January 2018

published in

Science Signaling

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8 January 2018

volume

9

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8 January 2018

issue

421

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8 January 2018

page(s)

ra32

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8 January 2018

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.

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Ovariectomy modulation of morphine analgesia of neuropathic pain is associated with the change of K( )-Cl(-) cotransporter 2 protein level in spinal dorsal horn.

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The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

17 June 2018

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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K -Cl- co-transporters

17 June 2018

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Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.

17 June 2018

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Comparative analysis of the expression profile of Wnk1 and Wnk1/Hsn2 splice variants in developing and adult mouse tissues

17 June 2018

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Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord

17 June 2018

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TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation

17 June 2018

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Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

17 June 2018

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T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity.

17 June 2018

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Sites of regulated phosphorylation that control K-Cl cotransporter activity

17 June 2018

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The prevalence and impact of chronic pain with neuropathic pain symptoms in the general population.

17 June 2018

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Sexually dimorphic expression of KCC2 and GABA function

17 June 2018

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Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II

17 June 2018

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Molecular physiology of the WNK kinases.

17 June 2018

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Pharmacological selectivity of CTAP in a warm water tail-withdrawal antinociception assay in rats

17 June 2018

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The case for the inclusion of female subjects in basic science studies of pain

17 June 2018

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Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

17 June 2018

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Human hypertension caused by mutations in WNK kinases

17 June 2018

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17 June 2018

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Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1

17 June 2018

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Spared nerve injury: an animal model of persistent peripheral neuropathic pain

17 June 2018

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Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons

17 June 2018

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The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

17 June 2018

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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

17 June 2018

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Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport?

17 June 2018

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Reduced potassium-chloride co-transporter expression in spinal cord dorsal horn neurons contributes to inflammatory pain hypersensitivity in rats

20 August 2018

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Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.

20 August 2018

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Differential maturation of GABA action and anion reversal potential in spinal lamina I neurons: impact of chloride extrusion capacity.

20 August 2018

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Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription.

20 August 2018

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Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

20 August 2018

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Crossref

https://api.crossref.org/works/10.1126/SCISIGNAL.AAD0163

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

21 January 2018

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Crossref

https://api.crossref.org/works/10.1126/SCISIGNAL.AAD0163

Comparison of three rodent neuropathic pain models

21 January 2018

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Crossref

https://api.crossref.org/works/10.1126/SCISIGNAL.AAD0163

Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27025876

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.AAD0163

1 reference

8 January 2018

PMC publication ID

5723157

1 reference

8 January 2018

PubMed publication ID

27025876

1 reference

8 January 2018