The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. (Q39850197)

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28 January 2020

title

The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells (English)

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28 January 2020

1

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28 January 2020

Elliot J. Androphy

5

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28 January 2020

author name string

I M Love

2

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28 January 2020

A N Imbalzano

3

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28 January 2020

S R Grossman

4

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28 January 2020

language of work or name

English

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publication date

18 May 2009

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28 January 2020

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28 January 2020

volume

28

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28 January 2020

issue

27

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28 January 2020

page(s)

2492-2501

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Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state

28 January 2020

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Chromatin dynamics and the preservation of genetic information

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Histone acetyltransferase complexes: one size doesn't fit all

22 September 2017

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p53 in health and disease

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Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency

22 September 2017

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The role of chromatin during transcription

22 September 2017

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Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control

22 September 2017

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22 September 2017

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Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers

22 September 2017

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Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage.

22 September 2017

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Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation

22 September 2017

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Tip60 in DNA damage response and growth control: many tricks in one HAT.

22 September 2017

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Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

22 September 2017

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p53 ubiquitination: Mdm2 and beyond

22 September 2017

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Brg1 is required for murine neural stem cell maintenance and gliogenesis

22 September 2017

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The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression

22 September 2017

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Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.

22 September 2017

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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions

22 September 2017

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The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway

22 September 2017

1 reference

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The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60

22 September 2017

1 reference

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

22 September 2017

1 reference

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MYC recruits the TIP60 histone acetyltransferase complex to chromatin

22 September 2017

1 reference

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Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

22 September 2017

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

22 September 2017

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Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes

22 September 2017

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Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal

22 September 2017

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The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

22 September 2017

1 reference

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SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription

22 September 2017

1 reference

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

22 September 2017

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The INK4a/ARF network in tumour suppression

22 September 2017

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When the SWI/SNF complex remodels...the cell cycle

22 September 2017

1 reference

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Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

Role of the LXCXE binding site in Rb function

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor

22 September 2017

1 reference

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Amplification of a gene encoding a p53-associated protein in human sarcomas

22 September 2017

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Cancer. p53, guardian of the genome

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.

22 September 2017

1 reference

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Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

Brg1 chromatin remodeling factor is involved in cell growth arrest, apoptosis and senescence of rat mesenchymal stem cells.

15 June 2018

1 reference

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Characterization of mammary tumors from Brg1 heterozygous mice.

20 August 2018

1 reference

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The reversible epigenetic silencing of BRM: implications for clinical targeted therapy.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708319

Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae

20 August 2018

1 reference

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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

20 August 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.121

The Proteasome Restricts Permissive Transcription at Tissue-Specific Gene Loci in Embryonic Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.121

Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.121

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.121

E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.121

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.121

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.121

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19448667 AND SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19448667 AND SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

19448667

1 reference