Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen (Q39824320)

14 September 2017

title

Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen (English)

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14 September 2017

John McLaughlin

1

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14 September 2017

Vadim Markovtsov

2

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14 September 2017

Hui Li

3

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14 September 2017

Steve Wong

4

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14 September 2017

Marina Gelman

5

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14 September 2017

Yanhong Zhu

6

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14 September 2017

Christian Franci

7

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14 September 2017

D Wayne Lang

8

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14 September 2017

Erlina Pali

9

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14 September 2017

Joe Lasaga

10

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14 September 2017

Caroline Low

11

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14 September 2017

Feifei Zhao

12

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14 September 2017

Betty Chang

13

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14 September 2017

Tarikere L Gururaja

14

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14 September 2017

Weiduan Xu

15

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14 September 2017

Muhammad Baluom

16

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14 September 2017

David Sweeny

17

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14 September 2017

David Carroll

18

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14 September 2017

Arvinder Sran

19

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14 September 2017

Sambaiah Thota

20

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14 September 2017

Manjeet Parmer

21

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14 September 2017

Angela Romane

22

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14 September 2017

George Clemens

23

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14 September 2017

Elliott Grossbard

24

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14 September 2017

Kunbin Qu

25

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14 September 2017

Yonchu Jenkins

26

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14 September 2017

Taisei Kinoshita

27

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14 September 2017

Vanessa Taylor

28

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14 September 2017

Sacha J Holland

29

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14 September 2017

Ankush Argade

30

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14 September 2017

Rajinder Singh

31

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14 September 2017

Polly Pine

32

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14 September 2017

Donald G Payan

33

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14 September 2017

Yasumichi Hitoshi

34

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14 September 2017

publication date

1 January 2010

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Journal of Cancer Research and Clinical Oncology

14 September 2017

published in

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14 September 2017

volume

136

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14 September 2017

issue

1

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14 September 2017

page(s)

99-113

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Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers.

14 September 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007/S00432-009-0641-1

Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007/S00432-009-0641-1

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

21 January 2018

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12 December 2020

AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis

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12 December 2020

The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer

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12 December 2020

MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy

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12 December 2020

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

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12 December 2020

The use of high-content screening for the discovery and characterization of compounds that modulate mitotic index and cell cycle progression by differing mechanisms of action

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12 December 2020

Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab

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12 December 2020

The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma.

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12 December 2020

The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases

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12 December 2020

Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas.

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12 December 2020

Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib

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12 December 2020

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

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12 December 2020

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors

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12 December 2020

Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

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12 December 2020

Targeting Aurora kinases for the treatment of prostate cancer

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12 December 2020

Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer

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12 December 2020

Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation

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12 December 2020

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast

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12 December 2020

Human TPX2 is required for targeting Aurora-A kinase to the spindle

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12 December 2020

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

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12 December 2020

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

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12 December 2020

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin

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12 December 2020

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

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12 December 2020

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

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12 December 2020

Amplification/overexpression of a mitotic kinase gene in human bladder cancer

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12 December 2020

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

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12 December 2020

Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer.

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12 December 2020

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition

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12 December 2020

Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors

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12 December 2020

Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial

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12 December 2020

AIM-1: a mammalian midbody-associated protein required for cytokinesis

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12 December 2020

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

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12 December 2020

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells

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12 December 2020

Aurora A: target invalidated?

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12 December 2020

Aurora B expression in normal testis and seminomas.

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12 December 2020

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.

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12 December 2020

The cellular geography of aurora kinases

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12 December 2020

STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis

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12 December 2020

Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis

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12 December 2020

Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma.

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12 December 2020

The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function

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12 December 2020

Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach

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12 December 2020

Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability

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12 December 2020

PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.

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12 December 2020

Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferation

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12 December 2020

Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

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12 December 2020

Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity

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12 December 2020

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

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12 December 2020

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

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12 December 2020

Molecular basis of drug resistance in aurora kinases

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12 December 2020

Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival.

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12 December 2020

Overexpression and amplification of Aurora-A in hepatocellular carcinoma

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12 December 2020

The expression of the aurora-A gene and its significance with tumorgenesis in non-Hodgkin's lymphoma

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12 December 2020

Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer

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12 December 2020

Targeting microtubules for cancer chemotherapy

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12 December 2020

INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow.

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12 December 2020

Aurora-A over-expression in high-grade PIN lesions and prostate cancer

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12 December 2020

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

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12 December 2020

Primary Bioassay of Human Tumor Stem Cells

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12 December 2020

Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma

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12 December 2020

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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12 December 2020

RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.

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12 December 2020

Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.

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12 December 2020

High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas

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12 December 2020

Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer

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12 December 2020

Aurora-A - a guardian of poles

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12 December 2020

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

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12 December 2020

10.1007/S00432-009-0641-1

Identifiers

DOI

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14 September 2017

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