AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K. (Q39791614)

14 September 2017

title

AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K. (English)

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14 September 2017

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J M Askham

1

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14 September 2017

F Platt

2

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14 September 2017

P A Chambers

3

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14 September 2017

H Snowden

4

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14 September 2017

C F Taylor

5

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14 September 2017

M A Knowles

6

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14 September 2017

language of work or name

English

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publication date

5 October 2009

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14 September 2017

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14 September 2017

volume

29

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14 September 2017

issue

1

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14 September 2017

page(s)

150-155

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describes a project that uses

14 September 2017

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Somatic mutation of PTEN in bladder carcinoma

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https://api.crossref.org/works/10.1038/ONC.2009.315

Akt activation by growth factors is a multiple-step process: the role of the PH domain

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

AKT1(E17K) in human solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.315

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

A new mutational AKTivation in the PI3K pathway

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Ca(2 )/calmodulin directly interacts with the pleckstrin homology domain of AKT1.

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Exploiting the PI3K/AKT pathway for cancer drug discovery

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Signaling intricacies take center stage in cancer cells

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

The protooncogene TCL1 is an Akt kinase coactivator

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.315

Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.315

AKT/PKB signaling: navigating downstream

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.315

Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.315

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.315

Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.315

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer

31 March 2020

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https://api.crossref.org/works/10.1038/ONC.2009.315

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.315

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release_novs6zkgejftxjut446aqeapgi

14 September 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/novs6zkgejftxjut446aqeapgi

mapped directly with Wikidata item

24 November 2022

based on heuristic

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