Calcineurin inhibitors activate the proto-oncogene Ras and promote protumorigenic signals in renal cancer cells (Q39776480)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19903851 AND SRC:MED&resulttype=core&format=json

12 February 2020

title

Calcineurin inhibitors activate the proto-oncogene Ras and promote protumorigenic signals in renal cancer cells (English)

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12 February 2020

4

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12 February 2020

David M. Briscoe

6

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12 February 2020

author name string

Dipak Datta

1

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12 February 2020

Alan G Contreras

2

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12 February 2020

Aninda Basu

3

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12 February 2020

Evelyn Flynn

5

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12 February 2020

Soumitro Pal

7

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12 February 2020

language of work or name

English

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publication date

10 November 2009

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12 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19903851 AND SRC:MED&resulttype=core&format=json

12 February 2020

volume

69

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12 February 2020

issue

23

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12 February 2020

page(s)

8902-8909

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Calcineurin inhibitor nephrotoxicity

12 February 2020

cites work

1 reference

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Calcineurin inhibitors modulate CXCR3 splice variant expression and mediate renal cancer progression.

22 September 2017

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Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer

22 September 2017

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Ras isoform abundance and signalling in human cancer cell lines.

22 September 2017

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Immunosuppressive therapy and malignancy in organ transplant recipients: a systematic review

22 September 2017

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KSR and CNK: two scaffolds regulating RAS-mediated RAF activation

22 September 2017

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The janus face of immunosuppression - de novo malignancy after renal transplantation: the experience of the Transplantation Center Munich

22 September 2017

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Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis

22 September 2017

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Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer

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Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint

22 September 2017

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In vivo luminescent imaging of cyclosporin A-mediated cancer progression in rats

22 September 2017

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Raf kinase inhibitor protein regulation of raf and MAPK signaling

22 September 2017

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Molecular basis of posttransplant squamous cell carcinoma: the potential role of cyclosporine a in carcinogenesis

22 September 2017

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Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review.

22 September 2017

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Cyclosporine: from renal transplantation to autoimmune diseases

22 September 2017

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Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis

22 September 2017

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Immunosuppression: practice and trends

22 September 2017

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Targeting RAS signalling pathways in cancer therapy

22 September 2017

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NFAT signaling: choreographing the social lives of cells

22 September 2017

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Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

22 September 2017

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Role of protein kinase Czeta in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression

22 September 2017

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Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

22 September 2017

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Essential role for oncogenic Ras in tumour maintenance

22 September 2017

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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

22 September 2017

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Proteins regulating Ras and its relatives

22 September 2017

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

22 September 2017

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

22 September 2017

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22 September 2017

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25 September 2017

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17 June 2018

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17 June 2018

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20 August 2018

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Cyclosporin induces renal proto-oncogene RNA message and increased transforming growth factor-beta prior to renal fibrosis: Modification by calcium channel blockade in the salt replete rat.

20 August 2018

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Immunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipients

20 August 2018

1 reference

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Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression

20 August 2018

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20 August 2018

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

20 August 2018

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Impact of acute rejection therapy on infections and malignancies in renal transplant recipients

20 August 2018

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20 August 2018

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Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

20 August 2018

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Cancer after kidney transplantation in the United States

20 August 2018

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12 December 2020

K-ras oncogene mutations in neoplasias of kidney transplanted patients: preliminary results with a new technique

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12 December 2020

Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin

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12 December 2020

Identifying High Risk Groups and Quantifying Absolute Risk of Cancer After Kidney Transplantation: A Cohort Study of 15 183 Recipients

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12 December 2020

10.1158/0008-5472.CAN-09-1404

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19903851 AND SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19903851 AND SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

19903851

1 reference