Rictor is a novel target of p70 S6 kinase-1. (Q39771171)

14 September 2017

title

Rictor is a novel target of p70 S6 kinase-1. (English)

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14 September 2017

3

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5

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14 September 2017

C Treins

1

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14 September 2017

P H Warne

series ordinal

2

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14 September 2017

M Pende

series ordinal

4

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14 September 2017

language of work or name

English

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publication date

23 November 2009

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14 September 2017

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14 September 2017

volume

29

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14 September 2017

issue

7

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14 September 2017

page(s)

1003-1016

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Rapamycin regulates the phosphorylation of rictor

14 September 2017

cites work

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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

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A quantitative atlas of mitotic phosphorylation

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1

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Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

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Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

21 January 2018

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

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Molecular mechanisms of mTOR-mediated translational control

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Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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SKAR is a specific target of S6 kinase 1 in cell growth control

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21 January 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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Identification of a conserved motif required for mTOR signaling

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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

21 January 2018

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

21 January 2018

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Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry

21 January 2018

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31 March 2020

Identifiers

DOI

10.1038/ONC.2009.401

1 reference

14 September 2017

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