Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer. (Q39763233)

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15 January 2020

title

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer (English)

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15 January 2020

7

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15 January 2020

author name string

T Komiya

1

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15 January 2020

A Coxon

2

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15 January 2020

Y Park

3

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15 January 2020

W-D Chen

4

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15 January 2020

M Zajac-Kaye

5

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15 January 2020

P Meltzer

6

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15 January 2020

F J Kaye

8

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15 January 2020

language of work or name

English

0 references

publication date

14 December 2009

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15 January 2020

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15 January 2020

volume

29

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15 January 2020

issue

11

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15 January 2020

page(s)

1672-1680

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Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma

15 January 2020

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Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins

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Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature

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LKB1: a sweet side to Peutz-Jeghers syndrome?

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SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis

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TORCs: transducers of regulated CREB activity

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Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes

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Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.

21 January 2018

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Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors

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Using kinomics to delineate signaling pathways: control of CRTC2/TORC2 by the AMPK family.

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

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LKB1; linking cell structure and tumor suppression

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Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer

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Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

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Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

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Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells

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LKB1 modulates lung cancer differentiation and metastasis

21 January 2018

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Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade

21 January 2018

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Emerging biology of malignant salivary gland tumors offers new insights into the classification and treatment of mucoepidermoid cancer

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Mutation-associated fusion cancer genes in solid tumors.

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Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast

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Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis

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Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation

21 January 2018

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TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity

21 January 2018

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Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion

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TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons.

21 January 2018

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Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells

21 January 2018

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

21 January 2018

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

21 January 2018

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NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism

21 January 2018

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Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression

21 January 2018

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A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

21 January 2018

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The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

21 January 2018

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LKB1 and lung cancer: more than the usual suspects

21 January 2018

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The LKB1 tumor suppressor negatively regulates mTOR signaling

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

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Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

21 January 2018

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CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior

21 January 2018

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t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway

21 January 2018

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Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells.

21 January 2018

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The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila

21 January 2018

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Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation

21 January 2018

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21 January 2018

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The LKB1 tumor suppressor kinase in human disease

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20010869

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20010869

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

NR4A1, 2, 3--an orphan nuclear hormone receptor family involved in cell apoptosis and carcinogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20010869

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2009.453

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20010869 AND SRC:MED&resulttype=core&format=json

15 January 2020

1 reference