A causative link between the structure of aberrant protein oligomers and their toxicity. (Q39750915)

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16 January 2020

title

A causative link between the structure of aberrant protein oligomers and their toxicity (English)

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16 January 2020

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8

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16 January 2020

Cristina Cecchi

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16 January 2020

author name string

Silvia Campioni

1

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16 January 2020

Benedetta Mannini

2

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16 January 2020

Mariagioia Zampagni

3

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16 January 2020

Anna Pensalfini

4

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16 January 2020

Claudia Parrini

5

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16 January 2020

Elisa Evangelisti

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16 January 2020

Annalisa Relini

7

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16 January 2020

Fabrizio Chiti

11

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16 January 2020

Christopher M Dobson

9

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16 January 2020

publication date

10 January 2010

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16 January 2020

published in

Nature Chemical Biology

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16 January 2020

volume

6

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16 January 2020

issue

2

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16 January 2020

page(s)

140-147

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Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain

16 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.283

Spectrofluorimetric assessment of the surface hydrophobicity of proteins

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.283

Comparative analysis of the cytotoxicity of homopolymeric amino acids

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.283

Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.283

Hydrogen/deuterium exchange mass spectrometry--a window into amyloid structure

21 January 2018

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12 December 2020

Fluorometric quantification of DNA in cells and tissue

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12 December 2020

Hydrophilicity of polar amino acid side-chains is markedly reduced by flanking peptide bonds

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12 December 2020

Study of the "molten globule" intermediate state in protein folding by a hydrophobic fluorescent probe

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12 December 2020

Surface structure of amyloid-beta fibrils contributes to cytotoxicity

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12 December 2020

Intracellular localization of homopolymeric amino acid-containing proteins expressed in mammalian cells

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12 December 2020

Cell systems and the toxic mechanism(s) of alpha-synuclein

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12 December 2020

Amyloid formation from HypF-N under conditions in which the protein is initially in its native state

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12 December 2020

Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway

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12 December 2020

Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer

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12 December 2020

MOLMOL: a program for display and analysis of macromolecular structures

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

Prefibrillar amyloid protein aggregates share common features of cytotoxicity.

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Correlation of beta-amyloid aggregate size and hydrophobicity with decreased bilayer fluidity of model membranes

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Multiparametric fluorescence detection of early stages in the amyloid protein aggregation of pyrene-labeled alpha-synuclein

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Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

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Prefibrillar amyloid aggregates could be generic toxins in higher organisms.

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12 December 2020

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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12 December 2020

Structural mapping of an aggregation nucleation site in a molten globule intermediate

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12 December 2020

Spectroscopic evidence for the existence of an obligate pre-fibrillar oligomer during glucagon fibrillation

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12 December 2020

Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content

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12 December 2020

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

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12 December 2020

Neurodegeneration in familial amyloid polyneuropathy: from pathology to molecular signaling

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12 December 2020

Structural insights into a yeast prion illuminate nucleation and strain diversity

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12 December 2020

Crystal structure and anion binding in the prokaryotic hydrogenase maturation factor HypF acylphosphatase-like domain

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12 December 2020

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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12 December 2020

Protein misfolding, functional amyloid, and human disease

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The most infectious prion protein particles.

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12 December 2020

Conformational properties of the aggregation precursor state of HypF-N.

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12 December 2020

Specific binding of amyloid-beta-protein to IMR-32 neuroblastoma cell membrane

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12 December 2020

Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity

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12 December 2020

Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

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12 December 2020

Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders

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12 December 2020

Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity.

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12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

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12 December 2020

Molecular mechanisms of amyloidosis

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12 December 2020

Excimers and Exciplexes

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.283

7 January 2021