The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation. (Q39740388)

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18 January 2020

title

The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation (English)

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18 January 2020

4

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18 January 2020

Leena Bruckner-Tuderman

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object named as

Leena Bruckner-Tuderman

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18 January 2020

author name string

Stefanie Löffek

1

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18 January 2020

Stefan Wöll

2

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18 January 2020

Jörg Höhfeld

3

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18 January 2020

Cristina Has

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18 January 2020

Thomas M Magin

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18 January 2020

publication date

1 April 2010

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18 January 2020

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18 January 2020

volume

31

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18 January 2020

issue

4

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18 January 2020

page(s)

466-476

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Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex

18 January 2020

cites work

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To be, or not to be--molecular chaperones in protein degradation

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A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice

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CHIP activates HSF1 and confers protection against apoptosis and cellular stress

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Cooperation of molecular chaperones with the ubiquitin/proteasome system

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Intermediate filaments are dynamic and motile elements of cellular architecture

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A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice

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Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells

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Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex

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Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm

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Abnormal organization of keratin intermediate filaments in cultured keratinocytes of epidermolysis bullosa simplex

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Keratinocytes and Fibroblasts from a Patient with Mutilating Dystrophic Epidermolysis Bullosa Synthesize Drastically Reduced Amounts of Collagen VII: Lack of Effect of Transforming Growth Factor-β

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Keratins turn over by ubiquitination in a phosphorylation-modulated fashion

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The chemical chaperone trimethylamine N-oxide ameliorates the effects of mutant keratins in cultured cells

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Observation of keratin particles showing fast bidirectional movement colocalized with microtubules

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Induction of Inflammatory Cytokines by a Keratin Mutation and their Repression by a Small Molecule in a Mouse Model for EBS

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Structural and regulatory functions of keratins.

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Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways

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Modulation of neurodegeneration by molecular chaperones

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Dominant cataract formation in association with a vimentin assembly disrupting mutation

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Intermediate filament proteins and their associated diseases

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Identification of a keratin-associated protein with a putative role in vesicle transport

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Chaperone functions of the E3 ubiquitin ligase CHIP.

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7 January 2021

Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex

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7 January 2021

Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes.

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7 January 2021

Update on the pathogenesis of Parkinson's disease

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7 January 2021

New consensus nomenclature for mammalian keratins

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7 January 2021

"Toxic memory" via chaperone modification is a potential mechanism for rapid Mallory-Denk body reinduction.

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7 January 2021

CHIP targets toxic alpha-Synuclein oligomers for degradation

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7 January 2021

Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants

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7 January 2021

Degradation of CFTR by the ubiquitin-proteasome pathway

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7 January 2021

The Mrj co-chaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta

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7 January 2021

Epidermolysis bullosa simplex-type mutations alter the dynamics of the keratin cytoskeleton and reveal a contribution of actin to the transport of keratin subunits.

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7 January 2021

Focal adhesions are hotspots for keratin filament precursor formation

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7 January 2021

Dissection of keratin dynamics: different contributions of the actin and microtubule systems

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p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells.

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7 January 2021

An autocrine/paracrine loop linking keratin 14 aggregates to tumor necrosis factor alpha-mediated cytotoxicity in a keratinocyte model of epidermolysis bullosa simplex

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From Mallory to Mallory-Denk bodies: what, how and why?

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Keratin 20 helps maintain intermediate filament organization in intestinal epithelia

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7 January 2021