Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). (Q39703203)

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English	Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).	scientific article

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14 September 2017

Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). (English)

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14 September 2017

Colleen M. Niswender

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Colleen M Niswender

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P. Jeffrey Conn

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P Jeffrey Conn

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Craig W. Lindsley

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Craig W Lindsley

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14 September 2017

Shaun R Stauffer

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Shaun R Stauffer

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Hilde Lavreysen

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Hilde Lavreysen

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Claire Mackie

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14 September 2017

Susana Conde-Ceide

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Susana Conde-Ceide

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Thomas Steckler

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Thomas Steckler

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Meredith J Noetzel

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Meredith J Noetzel

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14 September 2017

José Manuel Bartolomé-Nebreda

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José Manuel Bartolomé-Nebreda

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14 September 2017

Maria da Luz Martins

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María Luz Martín-Martín

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14 September 2017

Sergio A Alonso de Diego

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Sergio A Alonso de Diego

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14 September 2017

Carlos M Martínez-Viturro

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Carlos M Martínez-Viturro

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14 September 2017

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Carrie K Jones

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14 September 2017

author name string

Silvia López

5

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14 September 2017

Han Min Tong

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14 September 2017

Gregor J Macdonald

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14 September 2017

Thomas M Bridges

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14 September 2017

J Scott Daniels

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14 September 2017

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publication date

28 January 2015

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14 September 2017

Bioorganic & Medicinal Chemistry Letters

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14 September 2017

25

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14 September 2017

6

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14 September 2017

1310-1317

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14 September 2017

Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).

1 reference

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14 September 2017

Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).

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Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolin

1 reference

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14 September 2017

Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor

1 reference

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Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism

1 reference

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14 September 2017

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity

1 reference

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Glutamatergic transmission in schizophrenia: from basic research to clinical practice

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From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

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"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

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14 September 2017

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

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Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.

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Metabotropic glutamate receptor-dependent long-term potentiation

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mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

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Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory

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Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activiti

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The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia.

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Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm

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Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex

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Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo

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12 December 2020

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10.1016/J.BMCL.2015.01.038

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Europe PubMed Central

PMC publication ID

14 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

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Europe PubMed Central

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14 September 2017

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