High cytoplasmic expression of p27(Kip1) is associated with a worse cancer-specific survival in clear cell renal cell carcinoma (Q39699800)

14 September 2017

title

High cytoplasmic expression of p27(Kip1) is associated with a worse cancer-specific survival in clear cell renal cell carcinoma (English)

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Christian Eyrich

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Stephan Kruck

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Stephan Kruck

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Jens Bedke

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Jens Bedke

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author name string

Axel S Merseburger

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Joerg Hennenlotter

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Marcus Scharpf

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Bastian Amend

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Karl-Dietrich Sievert

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Arnulf Stenzl

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publication date

7 October 2011

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volume

109

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issue

10

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page(s)

1565-1570

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Renal cell carcinoma guideline

14 September 2017

cites work

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Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways

21 January 2018

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Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

21 January 2018

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Mining tissue microarray data to uncover combinations of biomarker expression patterns that improve intermediate staging and grading of clear cell renal cell cancer

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Loss of nuclear p27(kip1) and α-dystroglycan is a frequent event and is a strong predictor of poor outcome in renal cell carcinoma

21 January 2018

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The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma

21 January 2018

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Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma.

21 January 2018

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

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Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34 cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity

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Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells

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The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma

21 January 2018

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Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors

21 January 2018

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Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models

21 January 2018

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Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

21 January 2018

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Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro

21 January 2018

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Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo

21 January 2018

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10.1111/J.1464-410X.2011.10649.X

21 January 2018

Identifiers

DOI

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14 September 2017

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