YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway. (Q39672848)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20676745 AND SRC:MED&resulttype=core&format=json

9 February 2020

title

YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway (English)

1 reference

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9 February 2020

main subject

multiple drug resistance

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2

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9 February 2020

author name string

Chin-Chuan Hung

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20676745 AND SRC:MED&resulttype=core&format=json

9 February 2020

publication date

31 July 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20676745 AND SRC:MED&resulttype=core&format=json

Investigational New Drugs

9 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20676745 AND SRC:MED&resulttype=core&format=json

9 February 2020

volume

29

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20676745 AND SRC:MED&resulttype=core&format=json

9 February 2020

issue

6

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9 February 2020

page(s)

1337-1346

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ABC multidrug transporters: structure, function and role in chemoresistance.

9 February 2020

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ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells

21 January 2018

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21 January 2018

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Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

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Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

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Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation

21 January 2018

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Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.

21 January 2018

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An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function

21 January 2018

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Nitric oxide and cell death

21 January 2018

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Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.

21 January 2018

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Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators

21 January 2018

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YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase

21 January 2018

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YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9.

21 January 2018

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YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function

21 January 2018

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The inhibitory mechanism of YC-1, a benzyl indazole, on smooth muscle cell proliferation: an in vitro and in vivo study.

21 January 2018

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Versatile pharmacological actions of YC-1: anti-platelet to anticancer

21 January 2018

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YC-1 prevents sodium nitroprusside-mediated apoptosis in vascular smooth muscle cells

21 January 2018

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Pharmacogenomics of MDR1/ABCB1 gene: the influence on risk and clinical outcome of haematological malignancies

21 January 2018

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Multidrug resistance transporters and modulation

21 January 2018

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YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway

21 January 2018

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YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia

21 January 2018

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Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading

21 January 2018

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Nitric-oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood-brain barrier

21 January 2018

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YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia.

21 January 2018

1 reference

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Suppression of hypoxia inducible factor-1alpha (HIF-1alpha) by YC-1 is dependent on murine double minute 2 (Mdm2).

21 January 2018

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YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells.

21 January 2018

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Combined application of camptothecin and the guanylate cyclase activator YC-1: Impact on cell death and apoptosis-related proteins in ovarian carcinoma cell lines

21 January 2018

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Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase

21 January 2018

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YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells

21 January 2018

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Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer

21 January 2018

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21 January 2018

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21 January 2018

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YC-1, a novel activator of platelet guanylate cyclase

21 January 2018

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12 December 2020

Biological prognostic factors in adult soft tissue sarcomas.

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12 December 2020

Nitric oxide modulation of human leukemia cell differentiation and gene expression

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12 December 2020

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12 December 2020

YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets.

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12 December 2020

Regulation of biosynthesis of nitric oxide.

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12 December 2020

Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux.

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12 December 2020

10.1007/S10637-010-9496-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20676745 AND SRC:MED&resulttype=core&format=json

9 February 2020

1 reference