Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development (Q39657434)

13 September 2017

title

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development (English)

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13 September 2017

Ryan E Morgan

1

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13 September 2017

Michael Trauner

2

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13 September 2017

Carlo J van Staden

3

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13 September 2017

Paul H Lee

4

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13 September 2017

Bharath Ramachandran

5

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13 September 2017

Michael Eschenberg

6

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13 September 2017

Cynthia A Afshari

7

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13 September 2017

Charles W Qualls

8

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13 September 2017

Ruth Lightfoot-Dunn

9

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13 September 2017

Hisham K Hamadeh

10

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13 September 2017

publication date

9 September 2010

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13 September 2017

published in

Toxicological Sciences

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13 September 2017

volume

118

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13 September 2017

issue

2

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13 September 2017

page(s)

485-500

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Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats

13 September 2017

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The human bile salt export pump: characterization of substrate specificity and identification of inhibitors

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Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing

21 January 2018

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The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

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Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

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Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration

21 January 2018

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The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

21 January 2018

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Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin

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21 January 2018

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Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans

21 January 2018

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Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis

21 January 2018

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Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone

21 January 2018

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De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis

21 January 2018

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Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

21 January 2018

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Transport, Metabolism, and Hepatotoxicity of Flutamide, Drug–Drug Interaction with Acetaminophen Involving Phase I and Phase II Metabolites

21 January 2018

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Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats

21 January 2018

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A patient with novel ABCB11 gene mutations with phenotypic transition between BRIC2 and PFIC2.

21 January 2018

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21 January 2018

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Differential inhibition of rat and human Na -dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Species-specific and age-dependent bile acid composition: aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Drug-induced hepatotoxicity: 2005.

21 January 2018

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https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Postulated carbon tetrachloride mode of action: a review

21 January 2018

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Clinical hepatotoxicity. Regulation and treatment with inducers of transport and cofactors.

21 January 2018

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https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Vectorial transport of bile salts across MDCK cells expressing both rat Na -taurocholate cotransporting polypeptide and rat bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Inhibition of bile acid transport across Na /taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

The apical conjugate efflux pump ABCC2 (MRP2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Mitochondrially-mediated toxicity of bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Hepatocellular transporters and cholestasis

21 January 2018

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https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Hepatobiliary transporters and drug-induced cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Histological patterns in drug-induced liver disease

21 January 2018

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Mitochondrially mediated synergistic cell killing by bile acids.

21 January 2018

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Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis.

21 January 2018

1 reference

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Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP).

21 January 2018

1 reference

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Prediction of drug-induced intrahepatic cholestasis: in vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Effect of thiazolidinediones on bile acid transport in rat liver

21 January 2018

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https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

The bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Bile salt transporters: molecular characterization, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Evaluation of drug-transporter interactions using in vitro and in vivo models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/TOXSCI/KFQ269

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFQ269

1 reference

13 September 2017

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