Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways. (Q39650219)

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14 February 2020

title

Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways (English)

1 reference

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Edgardo Rodriguez-Carballo

14 February 2020

author

1

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14 February 2020

Francesc Ventura

8

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Maria Cristina Manzanares-Céspedes

14 February 2020

4

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14 February 2020

Ramon Bartrons

6

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Antonio R García Susperregui

14 February 2020

3

object named as

Antonio R G Susperregui

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14 February 2020

author name string

Arnau Ulsamer

2

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14 February 2020

Eva Sánchez-García

5

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14 February 2020

José Luis Rosa

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14 February 2020

publication date

1 April 2011

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Journal of Bone and Mineral Research

14 February 2020

published in

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14 February 2020

volume

26

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14 February 2020

issue

4

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14 February 2020

page(s)

718-729

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Transcriptional control of skeletogenesis

14 February 2020

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The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

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BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38.

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BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation

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Smad transcription factors

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A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos

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BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.

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Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

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Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter

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Wingless signaling induces widespread chromatin remodeling of target loci.

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TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

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Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction

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Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene

21 January 2018

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