The storm has cleared: lessons from the CD28 superagonist TGN1412 trial (Q39631306)

13 September 2017

title

The storm has cleared: lessons from the CD28 superagonist TGN1412 trial (English)

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13 September 2017

Thomas Hünig

1

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13 September 2017

publication date

10 April 2012

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Nature Reviews Immunology

13 September 2017

published in

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13 September 2017

volume

12

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13 September 2017

issue

5

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13 September 2017

page(s)

317-318

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Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

13 September 2017

cites work

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Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling

21 January 2018

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Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies

21 January 2018

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Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice

21 January 2018

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Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4 effector memory T-cells

21 January 2018

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Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412.

21 January 2018

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Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis

21 January 2018

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21 January 2018

Lessons from TGN1412.

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Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients

21 January 2018

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

21 January 2018

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Toward experimental assessment of receptor occupancy: TGN1412 revisited

21 January 2018

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Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist

21 January 2018

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CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28

21 January 2018

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Mitogenic CD28 signals require the exchange factor Vav1 to enhance TCR signaling at the SLP-76-Vav-Itk signalosome

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI3192

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13 September 2017

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