Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells (Q39581111)

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scientific article published on January 1, 2011

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English	Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells	scientific article published on January 1, 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Bcl-2 upregulation induced by miR-21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells (English)

1 reference

10.1016/J.ARCMED.2011.01.006

https://api.crossref.org/works/10.1016/J.ARCMED.2011.01.006

26 November 2024

pancreatic cancer

1 reference

based on heuristic

inferred from title

apoptotic process

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based on heuristic

inferred from title

positive regulation of biological process

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21376256

26 November 2024

author name string

Jie Dong

1

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Yu-Pei Zhao

2

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Europe PubMed Central

PubMed publication ID

13 September 2017

Li Zhou

3

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Europe PubMed Central

PubMed publication ID

13 September 2017

Tai-Ping Zhang

4

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Europe PubMed Central

PubMed publication ID

13 September 2017

Ge Chen

5

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Europe PubMed Central

PubMed publication ID

13 September 2017

language of work or name

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National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21376256

26 November 2024

publication date

1 January 2011

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Europe PubMed Central

PubMed publication ID

13 September 2017

January 2011

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National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21376256

26 November 2024

full work available at URL

https://api.elsevier.com/content/article/PII:S0188440911000075?httpAccept=text/xml

1 reference

10.1016/J.ARCMED.2011.01.006

https://api.crossref.org/works/10.1016/J.ARCMED.2011.01.006

26 November 2024

https://api.elsevier.com/content/article/PII:S0188440911000075?httpAccept=text/plain

1 reference

10.1016/J.ARCMED.2011.01.006

https://api.crossref.org/works/10.1016/J.ARCMED.2011.01.006

26 November 2024

Archives of Medical Research

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Europe PubMed Central

PubMed publication ID

13 September 2017

42

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Europe PubMed Central

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13 September 2017

1

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Europe PubMed Central

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8-14

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Europe PubMed Central

PubMed publication ID

13 September 2017

Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1158/0008-5472.CAN-09-4598

The Hallmarks of Cancer

1

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26 November 2024

The Bcl-2 apoptotic switch in cancer development and therapy

2

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BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer

3

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Inhibition of AKT abrogates chemotherapy-induced NF-kappaB survival mechanisms: implications for therapy in pancreatic cancer

4

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Mitogen-activated protein kinases and chemoresistance in pancreatic cancer cells

5

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ERK/BCL-2 pathway in the resistance of pancreatic cancer to anoikis

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The functions of animal microRNAs

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26 November 2024

MicroRNAs: genomics, biogenesis, mechanism, and function

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miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth

9

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10.1016/J.ARCMED.2011.01.006

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MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression

10

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Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB

11

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Involvement of microRNA-21 in mediating chemo-resistance to docetaxel in androgen-independent prostate cancer PC3 cells

12

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10.1016/J.ARCMED.2011.01.006

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MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

13

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26 November 2024

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

14

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MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

15

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MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells

16

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microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells

17

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microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2

18

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10.1016/J.ARCMED.2011.01.006

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microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells

19

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10.1016/J.ARCMED.2011.01.006

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MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity

20

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10.1016/J.ARCMED.2011.01.006

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Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status

21

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10.1016/J.ARCMED.2011.01.006

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Pancreatic cancer

22

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Expression of the bcl-2 gene and its significance in human pancreatic carcinoma

23

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TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway

24

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Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells

25

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10.1016/J.ARCMED.2011.01.006

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MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival

26

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MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance

27

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Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma

28

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MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity.

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Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer

31

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Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells

32

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MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation

33

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The interplay between the Bcl-2 family and death receptor-mediated apoptosis

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26 November 2024

Identifiers

10.1016/J.ARCMED.2011.01.006

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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