TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. (Q39532727)

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2 February 2020

title

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer (English)

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main subject

protein ubiquitination

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2

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Shyam Kumar Gudey

5

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Johan Ericsson

10

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Marene Landström

12

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author name string

Yabing Mu

1

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Noopur Thakur

3

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Maria Ekman

4

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Mariya Yakymovych

6

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Annika Hermansson

7

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Helen Dimitriou

8

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Maria Teresa Bengoechea-Alonso

9

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Carl-Henrik Heldin

11

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language of work or name

English

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publication date

1 January 2011

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published in

Nature Communications

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volume

2

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page(s)

330

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

2 February 2020

copyright license

start time

31 May 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta

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The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

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Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z

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Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

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Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding

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The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex

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Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3

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Crossref

https://api.crossref.org/works/10.1038/NCOMMS1332

What Determines the Specificity and Outcomes of Ubiquitin Signaling?

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Human transforming growth factor type beta 2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21629263

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21629263

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS1332

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2 February 2020

0 references

1 reference

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2 February 2020

PubMed publication ID

21629263

1 reference