Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents. (Q39417419)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22219386 AND SRC:MED&resulttype=core&format=json

19 January 2020

title

Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents (English)

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19 January 2020

2

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19 January 2020

author name string

Younghoon Kee

1

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19 January 2020

Sophia Chang

3

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19 January 2020

Lisa A Moreau

4

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19 January 2020

Eunmi Park

5

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19 January 2020

Peter G Smith

6

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19 January 2020

Alan D D'Andrea

7

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19 January 2020

publication date

4 January 2012

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Molecular Cancer Research

19 January 2020

published in

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19 January 2020

volume

10

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19 January 2020

issue

3

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19 January 2020

page(s)

369-377

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Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

19 January 2020

cites work

1 reference

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Mutations of the SLX4 gene in Fanconi anemia

11 September 2017

1 reference

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Control of cullin-ring ubiquitin ligase activity by nedd8.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells

11 September 2017

1 reference

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Cellular Responses to Cisplatin‐Induced DNA Damage

11 September 2017

1 reference

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Expanded roles of the Fanconi anemia pathway in preserving genomic stability

11 September 2017

1 reference

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Susceptibility pathways in Fanconi's anemia and breast cancer

11 September 2017

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Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

11 September 2017

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Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma

11 September 2017

1 reference

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Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

11 September 2017

1 reference

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

11 September 2017

1 reference

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E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

DNA repair pathways as targets for cancer therapy

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Proteasome function is required for DNA damage response and fanconi anemia pathway activation

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

FANCF methylation contributes to chemoselectivity in ovarian cancer

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Hsp90 regulates the Fanconi anemia DNA damage response pathway

14 September 2017

1 reference

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The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells

14 September 2017

1 reference

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ATR couples FANCD2 monoubiquitination to the DNA-damage response

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia.

25 September 2017

1 reference

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SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

17 June 2018

1 reference

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Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma

21 August 2018

1 reference

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The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307881

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22219386

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22219386

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1541-7786.MCR-11-0497

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22219386 AND SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22219386 AND SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

22219386

1 reference