Metabolic Reprogramming via PPARα Signaling in Cardiac Hypertrophy and Failure From Metabolomics to Epigenetics. (Q39395315)

PubMed publication ID

11 September 2017

1 reference

title

Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigenetics (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

Junichi Sadoshima

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

author name string

Shin-Ichi Oka

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

Daniela Zablocki

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

publication date

23 June 2017

1 reference

PubMed publication ID

28646024

American Journal of Physiology Heart and Circulatory Physiology

11 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

volume

313

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

page(s)

H584-H596

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

13 May 2020

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Differential regulation of stimulated glucose transport by free fatty acids and PPARα or -δ agonists in cardiac myocytes.

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The Failing Heart Relies on Ketone Bodies as a Fuel

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PPARγ stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPARγ regulating fetal growth

21 January 2018

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Revisiting PPARγ as a target for the treatment of metabolic disorders

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Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function

21 January 2018

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Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver

21 January 2018

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The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

21 January 2018

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MicroRNAs in lipid metabolism

21 January 2018

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A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes

21 January 2018

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Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart

21 January 2018

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The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus

21 January 2018

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Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles.

21 January 2018

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Multiple Interactions between Peroxisome Proliferators-Activated Receptors and the Ubiquitin-Proteasome System and Implications for Cancer Pathogenesis

21 January 2018

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Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis

21 January 2018

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PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet

21 January 2018

1 reference

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Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Nuclear receptor signaling and cardiac energetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin

21 January 2018

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CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Transmission of Metabolic Dysfunction Across Generations

21 January 2018

1 reference

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Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain

21 January 2018

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Activation of PPAR-α in the early stage of heart failure maintained myocardial function and energetics in pressure-overload heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Genome-wide histone methylation profile for heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Epigenetics across the human lifespan

21 January 2018

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Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure

21 January 2018

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Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure

21 January 2018

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Dietary fat supply to failing hearts determines dynamic lipid signaling for nuclear receptor activation and oxidation of stored triglyceride

21 January 2018

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Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach

21 January 2018

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Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators

21 January 2018

1 reference

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Normalization of NAD Redox Balance as a Therapy for Heart Failure

21 January 2018

1 reference

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

A role of miR-27 in the regulation of adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Myocardial fatty acid metabolism in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Transcriptional regulation of the human, porcine and bovine OCTN2 gene by PPARα via a conserved PPRE located in intron 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

The PPAR trio: regulators of myocardial energy metabolism in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

PPAR transcriptional activator complex polymorphisms and the promise of individualized therapy for heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Inhibition of peroxisome proliferator signaling pathways by thyroid hormone receptor. Competitive binding to the response element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

PPARα-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Peroxisome Proliferator Activated Receptor-α Association With Silent Information Regulator 1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

21 January 2018

1 reference

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Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure

21 January 2018

1 reference

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Metabolic modulation: a new therapeutic target in treatment of heart failure

21 January 2018

1 reference

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

21 January 2018

1 reference

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Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ

21 January 2018

1 reference

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Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR{alpha}/PGC1{alpha} and thermogenic glycerolipid/fatty acid cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

PGC-1 proteins and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Metabolomic analysis of pressure-overloaded and infarcted mouse hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Abnormal mitochondrial function in myocardium of dogs with chronic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Cardiac hypertrophy is enhanced in PPAR -/- mice in response to chronic pressure overload

21 January 2018

1 reference

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Lycium barbarum (Goji Berry) extracts and its taurine component inhibit PPAR-γ-dependent gene transcription in human retinal pigment epithelial cells: Possible implications for diabetic retinopathy treatment

21 January 2018

1 reference

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The language of covalent histone modifications

21 January 2018

1 reference

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SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Branched chain amino acid metabolic reprogramming in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Cardiac metabolism as a target for the treatment of heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

S100A8/MYD88/NF-қB: a novel pathway involved in cardiomyocyte hypertrophy driven by thyroid hormone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Effects of DNA methylation on DNA-binding proteins and gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Disturbed carnitine regulation in chronic heart failure--increased plasma levels of palmitoyl-carnitine are associated with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

21 January 2018

2 references

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

21 January 2018

12 December 2020

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Cardiac nuclear receptors: architects of mitochondrial structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

CD36 Deficiency Rescues Lipotoxic Cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

(13)C-based metabolic flux analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Histone methylations in heart development, congenital and adult heart diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPHEART.00103.2017

Serum carnitine concentrations in patients with idiopathic hypertrophic cardiomyopathy: relationship with impaired myocardial fatty acid metabolism

21 January 2018

1 reference

12 December 2020

DNA sequences responsible for reduced promoter activity of human phospholipid transfer protein by fibrate

1 reference

12 December 2020

Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity

1 reference

12 December 2020

Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunction

1 reference

12 December 2020

Insulin activates p38 mitogen-activated protein (MAP) kinase via a MAP kinase kinase (MKK) 3/MKK 6 pathway in vascular smooth muscle cells

1 reference

12 December 2020

Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport

1 reference

12 December 2020

Etomoxir: a new approach to treatment of chronic heart failure

1 reference

12 December 2020

Plasma carnitine levels as a marker of impaired left ventricular functions

1 reference

12 December 2020

A nuclear complex containing PPARalpha/RXRalpha is markedly downregulated in the hypertrophied rat left ventricular myocardium with normal systolic function

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart

1 reference

12 December 2020

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene

1 reference

12 December 2020

Does subclinical hypothyroidism affect cardiac pump performance? Evidence from a magnetic resonance imaging study

1 reference

12 December 2020

Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy

1 reference

12 December 2020

Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha

1 reference

12 December 2020

Transcriptomic analysis of PPARalpha-dependent alterations during cardiac hypertrophy

1 reference

12 December 2020

Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts

1 reference

12 December 2020

Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder

1 reference

12 December 2020

Rat hepatic mRNA-S14 and lipogenic enzymes during weaning: role of S14 in lipogenesis

1 reference

12 December 2020

Sodium dependence of carnitine transport in isolated perfused adult rat hearts

1 reference

12 December 2020

Methylation of CpG sequences in eukaryotic DNA

1 reference

12 December 2020

Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene.

1 reference

12 December 2020

Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts

1 reference

12 December 2020

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1 reference

12 December 2020

1 reference

12 December 2020

The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin

1 reference

12 December 2020

Regulation of mitochondrial [NADH] by cytosolic [Ca2 ] and work in trabeculae from hypertrophic and normal rat hearts

1 reference

12 December 2020

10.1152/AJPHEART.00103.2017

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6425516&resulttype=core&format=json

13 May 2020

PubMed publication ID

28646024

1 reference