MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells (Q39389252)

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24 January 2020

title

MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells (English)

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24 January 2020

1 reference

2

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24 January 2020

Joseph Gera

6

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24 January 2020

author name string

Y Shi

1

1 reference

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24 January 2020

B Hoang

3

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24 January 2020

Y Yang

4

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24 January 2020

R Fukunaga

5

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24 January 2020

A Lichtenstein

7

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24 January 2020

language of work or name

English

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publication date

27 February 2012

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24 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22370634 AND SRC:MED&resulttype=core&format=json

24 January 2020

volume

32

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24 January 2020

issue

2

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24 January 2020

page(s)

190-197

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Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.

24 January 2020

cites work

1 reference

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

11 September 2017

1 reference

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Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma

11 September 2017

1 reference

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Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling

11 September 2017

1 reference

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Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation

11 September 2017

1 reference

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MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines

11 September 2017

1 reference

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

11 September 2017

1 reference

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In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model

11 September 2017

1 reference

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Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

11 September 2017

1 reference

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Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression

11 September 2017

1 reference

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Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo

11 September 2017

1 reference

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The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

Internal ribosome entry segment-mediated initiation of c-Myc protein synthesis following genotoxic stress

11 September 2017

1 reference

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

11 September 2017

1 reference

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The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal-regulated kinase inhibitors and rapamycin.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401333

A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation

14 September 2017

1 reference

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IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1.

25 September 2017

1 reference

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Mnk is a negative regulator of cap-dependent translation in Aplysia neurons

17 June 2018

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Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.

21 August 2018

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Expression of poly(C)-binding proteins is differentially regulated by hypoxia and ischemia in cortical neurons

21 August 2018

1 reference

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Aberrant translational control of the c-myc gene in multiple myeloma.

21 August 2018

1 reference

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The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/ONC.2012.43

Oncogenes in multiple myeloma: point mutation of N-ras

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22370634

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2012.43

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22370634 AND SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

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24 January 2020

PubMed publication ID

22370634

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22370634 AND SRC:MED&resulttype=core&format=json