RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization (Q39384298)

11 September 2017

title

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization (English)

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11 September 2017

main subject

whole genome duplication

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2

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Thomas Mercher

9

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Olivier Bluteau

Olivier Bluteau

8

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Hana Raslova

Hana Raslova

14

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Catherine Léon

Catherine Leon

10

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William Vainchenker

13

William Vainchenker

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11 September 2017

Larissa Lordier

1

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11 September 2017

Abdelali Jalil

3

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11 September 2017

Céline Legrand

4

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11 September 2017

Jiajia Pan

5

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Philippe Rameau

6

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11 September 2017

Dima Jouni

7

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11 September 2017

Christian Gachet

11

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11 September 2017

Najet Debili

12

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Yunhua Chang

15

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11 September 2017

language of work or name

English

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publication date

6 March 2012

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11 September 2017

published in

Nature Communications

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11 September 2017

volume

3

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11 September 2017

page(s)

717

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Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells

11 September 2017

cites work

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12 December 2020

Myosin II activity is not essential for recruitment of myosin II to the furrow in dividing HeLa cells.

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12 December 2020

Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development.

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12 December 2020

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

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12 December 2020

Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation.

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12 December 2020

Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization

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12 December 2020

Dynamics of the contractile ring

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12 December 2020

Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation

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12 December 2020

Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens

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12 December 2020

Specificity of blebbistatin, an inhibitor of myosin II

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12 December 2020

Myosin II recruitment during cytokinesis independent of centralspindlin-mediated phosphorylation

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12 December 2020

Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression

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12 December 2020

Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression

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12 December 2020

Insights into familial platelet disorder with propensity to myeloid malignancy (FPD/AML)

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12 December 2020

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

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12 December 2020

Effects of cytokines on platelet production from blood and marrow CD34 cells

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12 December 2020

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12 December 2020

Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells

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12 December 2020

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

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12 December 2020

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

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12 December 2020

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

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12 December 2020

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.

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12 December 2020

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor

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12 December 2020

Enucleation of human erythroblasts involves non-muscle myosin IIB

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12 December 2020

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling.

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12 December 2020

Roads to polyploidy: the megakaryocyte example

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12 December 2020

Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process.

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12 December 2020

Megakaryocytes express functional Aurora-B kinase in endomitosis

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12 December 2020

Myosin-II-dependent localization and dynamics of F-actin during cytokinesis

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12 December 2020

Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesis

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12 December 2020

Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms

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12 December 2020

Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb

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12 December 2020

The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase

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12 December 2020

Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis

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12 December 2020

Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.

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12 December 2020

Historical review: megakaryopoiesis and thrombopoiesis

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12 December 2020

New roles for cyclin E in megakaryocytic polyploidization

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12 December 2020

Proplatelet formation is regulated by the Rho/ROCK pathway

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12 December 2020

Mechanism of blebbistatin inhibition of myosin II

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12 December 2020

Advances in the understanding of MYH9 disorders

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12 December 2020

Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes

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12 December 2020

Polyploidy and maturation of rat megakaryocytes

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12 December 2020

Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency

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12 December 2020

Identifiers

DOI

10.1038/NCOMMS1704

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11 September 2017

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