Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1. (Q39379039)

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23 March 2020

title

Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1 (English)

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Yiwei Wang

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language of work or name

English

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publication date

14 September 2016

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The American Journal of Pathology

23 March 2020

published in

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volume

186

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issue

11

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page(s)

2945-2956

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Cellular biology of prion diseases

23 March 2020

cites work

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12 December 2020

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

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12 December 2020

Filamins as integrators of cell mechanics and signalling

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12 December 2020

Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis

1 reference

12 December 2020

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

1 reference

12 December 2020

The many faces of filamin: a versatile molecular scaffold for cell motility and signalling

1 reference

12 December 2020

Notch-1 activation and dendritic atrophy in prion disease

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12 December 2020

Notch1 augments NF-kappaB activity by facilitating its nuclear retention

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12 December 2020

The Notch signaling pathway is related to neurovascular progression of pancreatic cancer.

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12 December 2020

Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

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12 December 2020

Cellular prion protein promotes invasion and metastasis of gastric cancer

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12 December 2020

Notch signalling: a simple pathway becomes complex

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12 December 2020

Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt

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12 December 2020

AIP4/Itch regulates Notch receptor degradation in the absence of ligand

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12 December 2020

A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains

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12 December 2020

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

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12 December 2020

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

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12 December 2020

Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

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12 December 2020

Antibodies to prion protein inhibit human colon cancer cell growth

1 reference

12 December 2020

Active Notch1 confers a transformed phenotype to primary human melanocytes

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12 December 2020

Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer

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12 December 2020

Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways

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12 December 2020

Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation

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12 December 2020

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12 December 2020

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

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12 December 2020

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

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12 December 2020

Binding of pro-prion to filamin A: by design or an unfortunate blunder

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12 December 2020

The multiple facets of ubiquitination in the regulation of notch signaling pathway.

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12 December 2020

Hallmarks of Cancer: The Next Generation

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12 December 2020

Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

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12 December 2020

Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.

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12 December 2020

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

1 reference

12 December 2020

Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think.

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12 December 2020

Potential roles for prions and protein-only inheritance in cancer

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12 December 2020

Dual regulation of notch1 signaling pathway by adaptor protein fe65

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12 December 2020

A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth

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12 December 2020

Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository

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12 December 2020

Metastatic pancreatic cancer is dependent on oncogenic Kras in mice

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12 December 2020

Significance of Notch1-signaling pathway in human pancreatic development and carcinogenesis

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12 December 2020

Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels

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12 December 2020

Oncogenic KRAS signalling in pancreatic cancer

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12 December 2020

Comprehensive genomic characterization of head and neck squamous cell carcinomas

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12 December 2020

Genomic analyses identify molecular subtypes of pancreatic cancer

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12 December 2020

Molecular cloning of a human prion protein cDNA

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12 December 2020

10.1016/J.AJPATH.2016.07.010

Identifiers

DOI

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PubMed publication ID

27639164

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