Epigenetic dysregulation of hematopoietic stem cells and preleukemic state (Q39337306)

11 September 2017

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title

Epigenetic dysregulation of hematopoietic stem cells and preleukemic state (English)

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11 September 2017

Hiroyoshi Kunimoto

1

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11 September 2017

Hideaki Nakajima

series ordinal

2

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11 September 2017

publication date

29 May 2017

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International Journal of Hematology

11 September 2017

published in

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11 September 2017

volume

106

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11 September 2017

issue

1

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11 September 2017

page(s)

34-44

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Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

11 September 2017

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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

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Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

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The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L.

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A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

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The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

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Dnmt3a is essential for hematopoietic stem cell differentiation

21 January 2018

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Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells

21 January 2018

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DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells

21 January 2018

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Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

21 January 2018

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Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.

21 January 2018

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Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.

21 January 2018

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DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

21 January 2018

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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

21 January 2018

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DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia

21 January 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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https://api.crossref.org/works/10.1007/S12185-017-2257-6

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

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https://api.crossref.org/works/10.1007/S12185-017-2257-6

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

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https://api.crossref.org/works/10.1007/S12185-017-2257-6

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

21 January 2018

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https://api.crossref.org/works/10.1007/S12185-017-2257-6

Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1

21 January 2018

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https://api.crossref.org/works/10.1007/S12185-017-2257-6

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells

21 January 2018

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https://api.crossref.org/works/10.1007/S12185-017-2257-6

Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.

21 January 2018

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https://api.crossref.org/works/10.1007/S12185-017-2257-6

TET2 promotes histone O-GlcNAcylation during gene transcription

21 January 2018

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Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells

21 January 2018

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TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

21 January 2018

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Mutation in TET2 in myeloid cancers

21 January 2018

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Acquired mutations in TET2 are common in myelodysplastic syndromes

21 January 2018

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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

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Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

21 January 2018

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TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

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Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.

21 January 2018

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Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

21 January 2018

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Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

21 January 2018

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

TET2 is essential for survival and hematopoietic stem cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Tet2-mutated myeloid progenitors possess aberrant in vitro self-renewal capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

ASXL1 plays an important role in erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Frequent mutation of BAP1 in metastasizing uveal melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

BAP1 loss defines a new class of renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Loss of the tumor suppressor BAP1 causes myeloid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Loss of BAP1 function leads to EZH2-dependent transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

Preleukemia: one name, many meanings

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12185-017-2257-6

LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).

21 January 2018

1 reference

12 December 2020

Clonal Origin of Chronic Myelocytic Leukemia

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12 December 2020

TET2 and DNMT3A mutations in human T-cell lymphoma

1 reference

12 December 2020

Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia

1 reference

12 December 2020

10.1007/S12185-017-2257-6

Identifiers

DOI

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11 September 2017

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