PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy. (Q39321762)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22751435 AND SRC:MED&resulttype=core&format=json

6 February 2020

title

PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy (English)

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6 February 2020

0 references

1 reference

1

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6 February 2020

Elliot J. Androphy

series ordinal

3

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6 February 2020

author name string

Alexander J Lakhter

series ordinal

2

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6 February 2020

publication date

15 July 2012

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6 February 2020

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6 February 2020

volume

11

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6 February 2020

issue

14

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6 February 2020

page(s)

2717-2728

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Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53

6 February 2020

cites work

1 reference

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Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression

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SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death

11 September 2017

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Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

11 September 2017

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CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.

11 September 2017

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Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53.

11 September 2017

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Blinded by the Light: The Growing Complexity of p53

11 September 2017

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11 September 2017

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Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding

11 September 2017

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11 September 2017

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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

11 September 2017

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SUMOylation and De-SUMOylation: wrestling with life's processes

11 September 2017

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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

11 September 2017

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Acetylation is indispensable for p53 activation

11 September 2017

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Regulation of TIP60 by ATF2 modulates ATM activation

11 September 2017

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

11 September 2017

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Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?

11 September 2017

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In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

11 September 2017

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GSK-3-mediated phosphorylation enhances Maf-transforming activity

11 September 2017

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p53 in health and disease

11 September 2017

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Monoubiquitylation promotes mitochondrial p53 translocation

11 September 2017

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

11 September 2017

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DRAM links autophagy to p53 and programmed cell death

11 September 2017

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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

11 September 2017

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The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis

11 September 2017

1 reference

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Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.

11 September 2017

1 reference

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Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression

11 September 2017

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PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

11 September 2017

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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

11 September 2017

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

11 September 2017

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Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

11 September 2017

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

11 September 2017

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Involvement of PIAS1 in the sumoylation of tumor suppressor p53

11 September 2017

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p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

11 September 2017

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Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

11 September 2017

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TRIM29 negatively regulates p53 via inhibition of Tip60.

11 September 2017

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The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression

14 September 2017

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The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

14 September 2017

1 reference

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The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells

14 September 2017

1 reference

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PUMA- and Bax-induced autophagy contributes to apoptosis

14 September 2017

1 reference

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GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines

14 September 2017

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C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

14 September 2017

1 reference

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

14 September 2017

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Nucleostemin: Another nucleolar "Twister" of the p53-MDM2 loop

25 September 2017

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p53: The Janus of autophagy?

17 June 2018

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Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

17 June 2018

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17 June 2018

The p53-Bcl-2 connection

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The Skp2 promoter integrates signaling through the NF-kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis.

17 June 2018

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A PAR-SUMOnious mechanism of NEMO activation.

21 August 2018

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The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways

21 August 2018

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An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells

21 August 2018

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction

21 August 2018

1 reference

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Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

21 August 2018

1 reference

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Induction of apoptosis in HeLa cells by trans-activation-deficient p53

21 August 2018

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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

21 August 2018

1 reference

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Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response

2 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3409012

p53--an examination of sibling support in apoptosis control

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22751435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22751435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/CC.21091

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22751435 AND SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22751435 AND SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

22751435

1 reference