Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model (Q39321386)

11 September 2017

title

Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model (English)

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11 September 2017

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9

Ulrich Bogdahn

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11 September 2017

10

Peter Hau

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11 September 2017

Sridhar R Chirasani

1

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11 September 2017

Petra Leukel

2

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11 September 2017

Eva Gottfried

3

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11 September 2017

Jochen Hochrein

4

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11 September 2017

Katrin Stadler

5

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11 September 2017

Bernhard Neumann

6

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11 September 2017

Peter J Oefner

7

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11 September 2017

Wolfram Gronwald

8

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11 September 2017

Marina Kreutz

11

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11 September 2017

Oliver M Grauer

12

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11 September 2017

language of work or name

English

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publication date

21 July 2012

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International Journal of Cancer

11 September 2017

number of pages

11

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based on heuristic

inferred from page(s)

published in

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11 September 2017

volume

132

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11 September 2017

issue

4

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11 September 2017

page(s)

843-853

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Hypoxia--a key regulatory factor in tumour growth

11 September 2017

cites work

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Hypoxia-inducible factors: central regulators of the tumor phenotype

21 January 2018

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HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

21 January 2018

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Lactate: mirror and motor of tumor malignancy

21 January 2018

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c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

21 January 2018

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Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis

21 January 2018

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Identification of MRI and 1H MRSI parameters that may predict survival for patients with malignant gliomas

21 January 2018

1 reference

Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma

21 January 2018

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Initiation of immune responses in brain is promoted by local dendritic cells

21 January 2018

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Dendritic cells: specialized and regulated antigen processing machines

21 January 2018

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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

21 January 2018

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Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3 regulatory T cells

21 January 2018

1 reference

Toll-like receptor control of the adaptive immune responses

21 January 2018

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

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Toll-like receptor triggered dendritic cell maturation and IL-12 secretion are necessary to overcome T-cell inhibition by glioma-associated TGF-beta2.

21 January 2018

1 reference

Dendritic cell dysfunction in cancer: a mechanism for immunosuppression

21 January 2018

1 reference

Tumor-induced modulation of dendritic cell function

21 January 2018

1 reference

Immunotherapy of diffuse gliomas: biological background, current status and future developments

21 January 2018

1 reference

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

21 January 2018

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Suppression of T-cell responses by tumor metabolites

21 January 2018

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Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo

21 January 2018

1 reference

Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen

21 January 2018

1 reference

Urinary metabolite quantification employing 2D NMR spectroscopy.

21 January 2018

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CD4 FoxP3 regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo

21 January 2018

1 reference

Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway

21 January 2018

1 reference

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

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Induction of a therapeutic antitumor immunological response by intratumoral injection of genetically engineered Semliki Forest virus to produce interleukin-12.

21 January 2018

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Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12.

21 January 2018

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The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses

21 January 2018

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Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment

21 January 2018

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The regulation of IL-10 production by immune cells

21 January 2018

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A critical role for Stat3 signaling in immune tolerance

21 January 2018

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A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients.

21 January 2018

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Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy

21 January 2018

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Cyclooxygenase-2 inhibition: a potential mechanism for increasing the efficacy of bacillus calmette-guerin immunotherapy for bladder cancer.

21 January 2018

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Foxp3 CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion

21 January 2018

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Toll-like receptor 2 controls expansion and function of regulatory T cells

21 January 2018

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Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma

21 January 2018

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COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells

21 January 2018

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TLR ligands in the local treatment of established intracerebral murine gliomas.

21 January 2018

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Immunomodulatory effects of diclofenac in leukocytes through the targeting of Kv1.3 voltage-dependent potassium channels

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.27712

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11 September 2017

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