Adenoviral delivery of Tousled kinase for the protection of salivary glands against ionizing radiation damage. (Q39277352)

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15 January 2020

title

Adenoviral delivery of Tousled kinase for the protection of salivary glands against ionizing radiation damage (English)

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15 January 2020

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Senthilnathan Palaniyandi

1

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15 January 2020

Yoshinobu Odaka

2

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15 January 2020

author name string

W Green

3

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15 January 2020

F Abreo

4

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15 January 2020

G Caldito

5

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15 January 2020

A De Benedetti

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15 January 2020

G Sunavala-Dossabhoy

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publication date

4 November 2010

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15 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048794 AND SRC:MED&resulttype=core&format=json

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volume

18

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issue

3

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15 January 2020

page(s)

275-282

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Management of patients who have undergone head and neck cancer therapy

15 January 2020

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Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.

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The Tousled gene in A. thaliana encodes a protein kinase homolog that is required for leaf and flower development

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TOUSLED participates in apical tissue formation during gynoecium development in Arabidopsis

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Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases

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Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions

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A dominant negative mutant of TLK1 causes chromosome missegregation and aneuploidy in normal breast epithelial cells

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TOUSLED kinase activity oscillates during the cell cycle and interacts with chromatin regulators.

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A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed

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The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks

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Tousled homolog, TLK1, binds and phosphorylates Rad9; TLK1 acts as a molecular chaperone in DNA repair.

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TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.

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Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis

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mars and tousled-like kinase act in parallel to ensure chromosome fidelity in Drosophila

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The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase.

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Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication

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Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint

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Tousled kinase TLK1B counteracts the effect of Asf1 in inhibition of histone H3-H4 tetramer formation

21 January 2018

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Tousled kinase TLK1B mediates chromatin assembly in conjunction with Asf1 regardless of its kinase activity

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Purification and identification of a protein kinase activity modulated by ionizing radiation

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Cationic liposome-mediated gene transfer to rat salivary epithelial cells in vitro and in vivo

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Evaluation of salivary gland acinar and ductal cell-specific promoters in vivo with recombinant adenoviral vectors

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Repetitive Adenovirus Administration to the Parotid Gland: Role of Immunological Barriers and Induction of Oral Tolerance

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Long-term salivary effects of single-dose head and neck irradiation in the rat.

21 January 2018

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Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model

21 January 2018

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Translation of the radioresistance kinase TLK1B is induced by gamma-irradiation through activation of mTOR and phosphorylation of 4E-BP1

21 January 2018

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Comparison of radiosensitivity of rat parotid and submandibular glands after different radiation schedules

21 January 2018

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Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis.

21 January 2018

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Suppression of radiation-induced salivary gland dysfunction by IGF-1.

21 January 2018

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Enhanced transduction of mouse salivary glands with AAV5-based vectors

21 January 2018

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AAV5-mediated gene transfer to the parotid glands of non-human primates

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Regulation of Ca(2 ) signals in a parotid cell line Par-C5.

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Radiation-induced progressive decrease in fluid secretion in rat submandibular glands is related to decreased acinar volume and not impaired calcium signaling

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Association between salivary flow rates, oral symptoms, and oral mucosal status

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7 January 2021

Correlation of TLK1B in elevation and recurrence in doxorubicin-treated breast cancer patients with high eIF4E overexpression

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7 January 2021

Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands

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7 January 2021

Chemoradiation-induced cell loss in human submandibular glands

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7 January 2021

Radiation induced cell loss in rat submandibular gland and its relation to gland function

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7 January 2021

Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients

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7 January 2021