Systemic iron homeostasis and erythropoiesis (Q39226004)

10 September 2017

title

Systemic iron homeostasis and erythropoiesis (English)

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10 September 2017

1

George Papanikolaou

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10 September 2017

Kostas Pantopoulos

2

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10 September 2017

publication date

6 April 2017

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10 September 2017

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10 September 2017

volume

69

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10 September 2017

issue

6

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10 September 2017

page(s)

399-413

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Iron metabolism and toxicity

10 September 2017

cites work

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Regulation of iron transport and the role of transferrin

21 January 2018

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Systemic iron homeostasis

21 January 2018

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Contributions of heme and nonheme iron to human nutrition

21 January 2018

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Mechanistic and regulatory aspects of intestinal iron absorption

21 January 2018

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Multi-copper oxidases and human iron metabolism

21 January 2018

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Dysfunction of the heme recycling system in heme oxygenase 1–deficient mice: effects on macrophage viability and tissue iron distribution

21 January 2018

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

21 January 2018

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Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

21 January 2018

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Primitive and definitive erythropoiesis in mammals

21 January 2018

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Mitoferrin is essential for erythroid iron assimilation

21 January 2018

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Transferrin receptor is necessary for development of erythrocytes and the nervous system

21 January 2018

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Global transcriptome analyses of human and murine terminal erythroid differentiation

21 January 2018

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Beyond soluble transferrin receptor: old challenges and new horizons

21 January 2018

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NCOA4 Deficiency Impairs Systemic Iron Homeostasis

21 January 2018

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Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.

21 January 2018

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Regulation of cellular iron metabolism

21 January 2018

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Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo

21 January 2018

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Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

21 January 2018

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The IRP/IRE system in vivo: insights from mouse models

21 January 2018

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Hypoxia-inducible factors link iron homeostasis and erythropoiesis

21 January 2018

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HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

21 January 2018

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Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency

21 January 2018

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Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

21 January 2018

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Iron regulatory proteins control a mucosal block to intestinal iron absorption

21 January 2018

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Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

21 January 2018

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Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis

21 January 2018

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Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression

21 January 2018

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N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program

21 January 2018

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

21 January 2018

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

21 January 2018

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

21 January 2018

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Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

21 January 2018

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Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype

21 January 2018

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Hepcidin: regulation of the master iron regulator

21 January 2018

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Iron homeostasis in host defence and inflammation

21 January 2018

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Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

21 January 2018

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Low hepcidin accounts for the proinflammatory status associated with iron deficiency.

21 January 2018

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

21 January 2018

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Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

21 January 2018

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Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

21 January 2018

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Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

21 January 2018

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Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

21 January 2018

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Hepcidin is decreased in TFR2 hemochromatosis

21 January 2018

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Knockout Mouse Models of Iron Homeostasis

21 January 2018

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SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

21 January 2018

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Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

21 January 2018

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Hepcidin regulation in the anemia of inflammation

21 January 2018

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Anemia of chronic disease.

21 January 2018

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Regulation of ferritin genes and protein

21 January 2018

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A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.

21 January 2018

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Pharmacological Targeting of the Hepcidin/Ferroportin Axis

21 January 2018

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

21 January 2018

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Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

21 January 2018

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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

21 January 2018

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Lack of the bone morphogenetic protein BMP6 induces massive iron overload

21 January 2018

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Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

21 January 2018

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Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

21 January 2018

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The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

21 January 2018

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Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

21 January 2018

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Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis

21 January 2018

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Hfe acts in hepatocytes to prevent hemochromatosis.

21 January 2018

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Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

21 January 2018

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Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin.

21 January 2018

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Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.

21 January 2018

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HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

21 January 2018

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A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

21 January 2018

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The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

21 January 2018

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Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

21 January 2018

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The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

21 January 2018

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Regulation of transferrin receptor 2 protein levels by transferrin

21 January 2018

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Diferric transferrin regulates transferrin receptor 2 protein stability

21 January 2018

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Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

21 January 2018

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In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact.

21 January 2018

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Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.

21 January 2018

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Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

21 January 2018

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Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

21 January 2018

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Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

21 January 2018

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Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

21 January 2018

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STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.

21 January 2018

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STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

21 January 2018

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Interleukin-6 induces hepcidin expression through STAT3

21 January 2018

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Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation

21 January 2018

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The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6.

21 January 2018

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Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

21 January 2018

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Regulation of hepcidin expression by inflammation-induced activin B.

21 January 2018

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Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.

21 January 2018

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Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B.

21 January 2018

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Hepcidin in the diagnosis of iron disorders

21 January 2018

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Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

21 January 2018

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

21 January 2018

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Hepcidin in iron overload disorders

21 January 2018

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Suppression of hepcidin during anemia requires erythropoietic activity

21 January 2018

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High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

21 January 2018

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Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I.

21 January 2018

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Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

21 January 2018

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The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice.

21 January 2018

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Identification of erythroferrone as an erythroid regulator of iron metabolism

21 January 2018

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Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

21 January 2018

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Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis

21 January 2018

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Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia

21 January 2018

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Characterization of Putative Erythroid Regulators of Hepcidin in Mouse Models of Anemia.

21 January 2018

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Erythropoietin and iron-restricted erythropoiesis

21 January 2018

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IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation

21 January 2018

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Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

21 January 2018

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The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption

21 January 2018

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Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis

21 January 2018

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Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response

21 January 2018

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Iron control of erythroid development by a novel aconitase-associated regulatory pathway

21 January 2018

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Isocitrate treatment of acute anemia of inflammation in a mouse model

21 January 2018

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Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis.

21 January 2018

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Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form.

21 January 2018

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Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia.

21 January 2018

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The second transferrin receptor regulates red blood cell production in mice

21 January 2018

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TfR2 links iron metabolism and erythropoiesis

21 January 2018

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The mutual control of iron and erythropoiesis.

21 January 2018

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Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

21 January 2018

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Identifiers

DOI

10.1002/IUB.1629

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10 September 2017

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