Drugging RAS: Know the enemy (Q39182842)

9 September 2017

title

Drugging RAS: Know the enemy (English)

1 reference

9 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28302824 AND SRC:MED&resulttype=core&format=json

1 June 2020

Channing Der

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28302824 AND SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Bjoern Papke

series ordinal

1

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9 September 2017

Channing J Der

series ordinal

2

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9 September 2017

language of work or name

English

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publication date

16 March 2017

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9 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28302824 AND SRC:MED&resulttype=core&format=json

1 June 2020

volume

355

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28302824 AND SRC:MED&resulttype=core&format=json

1 June 2020

issue

6330

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28302824 AND SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

1158-1163

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28302824 AND SRC:MED&resulttype=core&format=json

Drugging the undruggable RAS: Mission possible?

1 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Dragging ras back in the ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Small-molecule modulation of Ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

US National Cancer Institute's new Ras project targets an old foe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Ras history: The saga continues

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Drugging Undruggable Molecular Cancer Targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

RAS oncogenes: weaving a tumorigenic web

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

KRAS: feeding pancreatic cancer proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Regulating the regulator: post-translational modification of RAS

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Ras oncogenes: split personalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Identification of pyrazolopyridazinones as PDEδ inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Targeting RAS-mutant cancers: is ERK the key?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Targeting the PI3K signaling pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Genetically engineered mouse models of pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Targeting RAS-ERK signalling in cancer: promises and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

RAF inhibitors that evade paradoxical MAPK pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

The concept of synthetic lethality in the context of anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Pancreatic cancers require autophagy for tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAM7622