FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells (Q39165033)

9 September 2017

title

FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells (English)

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9 September 2017

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16

Cynthia Hawkins

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9 September 2017

Branavan Manoranjan

1

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9 September 2017

Xin Wang

2

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Robin M Hallett

3

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9 September 2017

Chitra Venugopal

4

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Stephen C Mack

5

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Nicole McFarlane

6

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9 September 2017

Sara M Nolte

7

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9 September 2017

Katrin Scheinemann

8

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9 September 2017

Thorsteinn Gunnarsson

9

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9 September 2017

John A Hassell

10

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9 September 2017

Michael D Taylor

11

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9 September 2017

Cathy Lee

12

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9 September 2017

Joanna Triscott

13

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Colleen M Foster

14

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9 September 2017

Christopher Dunham

15

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9 September 2017

Sandra E Dunn

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9 September 2017

Sheila K Singh

18

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9 September 2017

publication date

1 July 2013

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9 September 2017

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9 September 2017

volume

31

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issue

7

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9 September 2017

page(s)

1266-1277

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Medulloblastoma in childhood: new biological advances

9 September 2017

cites work

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Medulloblastoma: signalling a change in treatment

21 January 2018

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Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma

21 January 2018

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Childhood medulloblastoma: novel approaches to the classification of a heterogeneous disease

21 January 2018

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Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification

21 January 2018

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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

21 January 2018

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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

21 January 2018

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Medulloblastoma comprises four distinct molecular variants

21 January 2018

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Prediction of central nervous system embryonal tumour outcome based on gene expression

21 January 2018

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Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

21 January 2018

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beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee

21 January 2018

1 reference

Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics

21 January 2018

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Molecular subgroups of medulloblastoma: the current consensus

21 January 2018

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Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

21 January 2018

1 reference

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1( /-)p53(-/-) mice

21 January 2018

1 reference

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

21 January 2018

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An animal model of MYC-driven medulloblastoma

21 January 2018

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A mouse model of the most aggressive subgroup of human medulloblastoma

21 January 2018

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FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

21 January 2018

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

21 January 2018

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The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.

21 January 2018

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Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation

21 January 2018

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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

21 January 2018

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Stem cells, cancer, and cancer stem cells

21 January 2018

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Identification of human brain tumour initiating cells

21 January 2018

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Mammalian neural stem cells

21 January 2018

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Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell

21 January 2018

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Neurosphere formation is an independent predictor of clinical outcome in malignant glioma

21 January 2018

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Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis.

21 January 2018

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Exploration, normalization, and summaries of high density oligonucleotide array probe level data

21 January 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

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Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.

21 January 2018

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Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells.

21 January 2018

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

21 January 2018

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Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma

21 January 2018

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Multipotent CD15 cancer stem cells in patched-1-deficient mouse medulloblastoma

21 January 2018

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

21 January 2018

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Identification and expansion of human colon-cancer-initiating cells

21 January 2018

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Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain

21 January 2018

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The neural progenitor-specifying activity of FoxG1 is antagonistically regulated by CKI and FGF.

21 January 2018

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Crypt stem cells as the cells-of-origin of intestinal cancer

21 January 2018

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Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity.

21 January 2018

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The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network

21 January 2018

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NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation

21 January 2018

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Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.

21 January 2018

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Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1.

21 January 2018

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Expression analysis of stem cell-related genes reveal OCT4 as a predictor of poor clinical outcome in medulloblastoma

21 January 2018

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Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor.

21 January 2018

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Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile

21 January 2018

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Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas

21 January 2018

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Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas

21 January 2018

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Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression

21 January 2018

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Telomere maintenance in childhood primitive neuroectodermal brain tumors

21 January 2018

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Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

21 January 2018

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TWIST1 promotes invasion through mesenchymal change in human glioblastoma

21 January 2018

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Subtypes of medulloblastoma have distinct developmental origins

21 January 2018

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A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs

21 January 2018

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FOXG1 dysregulation is a frequent event in medulloblastoma

21 January 2018

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Subgroup-specific structural variation across 1,000 medulloblastoma genomes

21 January 2018

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Overexpression of FOXG1 contributes to TGF-beta resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer

21 January 2018

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shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development

21 January 2018

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Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors

21 January 2018

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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

21 January 2018

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Bmi1 marks intermediate precursors during differentiation of human brain tumor initiating cells

21 January 2018

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Clinical and molecular stratification of disease risk in medulloblastoma

21 January 2018

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The origins of medulloblastoma subtypes

21 January 2018

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Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.1401

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9 September 2017

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