Manufacturing of recombinant adeno-associated viruses using mammalian expression platforms (Q39126013)

9 September 2017

title

Manufacturing of recombinant adeno-associated viruses using mammalian expression platforms (English)

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9 September 2017

Marc-André Robert

1

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9 September 2017

Parminder S Chahal

2

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9 September 2017

Alexandre Audy

3

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9 September 2017

Amine Kamen

4

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9 September 2017

Rénald Gilbert

5

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9 September 2017

Bruno Gaillet

6

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9 September 2017

publication date

8 February 2017

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9 September 2017

published in

Biotechnology Journal

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9 September 2017

volume

12

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9 September 2017

issue

3

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Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus.

9 September 2017

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Manufacturing of recombinant adeno-associated viral vectors for clinical trials

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Scalable recombinant adeno-associated virus production using recombinant herpes simplex virus type 1 coinfection of suspension-adapted mammalian cells

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Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector

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Manufacturing recombinant adeno-associated viral vectors from producer cell clones

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Basic biology of adeno-associated virus (AAV) vectors used in gene therapy

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Adeno-Associated Virus Biology

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Adeno-associated virus site-specific integration and AAVS1 disruption

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Characterization of genome integrity for oversized recombinant AAV vector

21 January 2018

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Effect of genome size on AAV vector packaging

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Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo

21 January 2018

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Self-complementary AAV vectors; advances and applications

21 January 2018

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Development of formulations that enhance physical stability of viral vectors for gene therapy.

21 January 2018

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Stability and compatibility of recombinant adeno-associated virus under conditions commonly encountered in human gene therapy trials

21 January 2018

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A simplified purification protocol for recombinant adeno-associated virus vectors.

21 January 2018

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Comparative analysis of adeno-associated virus capsid stability and dynamics

21 January 2018

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Feasibility of generating adeno-associated virus packaging cell lines containing inducible adenovirus helper genes

21 January 2018

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Rep/Cap gene amplification and high-yield production of AAV in an A549 cell line expressing Rep/Cap.

21 January 2018

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Large-scale adeno-associated viral vector production using a herpesvirus-based system enables manufacturing for clinical studies

21 January 2018

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Manufacturing of recombinant adeno-associated viral vectors: new technologies are welcome

21 January 2018

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Current issues in adeno-associated viral vector production

21 January 2018

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Transient transfection methods for clinical adeno-associated viral vector production

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Novel tools for production and purification of recombinant adenoassociated virus vectors

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

A helper virus-free packaging system for recombinant adeno-associated virus vectors

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Rational plasmid design and bioprocess optimization to enhance recombinant adeno-associated virus (AAV) productivity in mammalian cells

21 January 2018

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Strategies to generate high-titer, high-potency recombinant AAV3 serotype vectors

21 January 2018

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Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Large-Scale Production of Adeno-Associated Viral Vector Serotype-9 Carrying the Human Survival Motor Neuron Gene

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Evaluation of a Serum-free Medium for the Production of rAAV-2 using HeLa Derived Producer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Cell lines for the production of recombinant adeno-associated virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Development and characterization of a cell line for large-scale, serum-free production of recombinant adeno-associated viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Generation and characterization of adeno-associated virus producer cell lines for research and preclinical vector production

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

A novel gene expression control system and its use in stable, high-titer 293 cell-based adeno-associated virus packaging cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

A Versatile Adeno-Associated Virus Vector Producer Cell Line Method for Scalable Vector Production of Different Serotypes

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

High-titer adeno-associated viral vectors from a Rep/Cap cell line and hybrid shuttle virus

21 January 2018

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A scalable method for the production of high-titer and high-quality adeno-associated type 9 vectors using the HSV platform

21 January 2018

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An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap.

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Efficient serotype-dependent release of functional vector into the culture medium during adeno-associated virus manufacturing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Recombinant adeno-associated viral vector production and purification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

AAV2/8 vectors purified from culture medium with a simple and rapid protocol transduce murine liver, muscle, and retina efficiently

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Simple downstream process based on detergent treatment improves yield and in vivo transduction efficacy of adeno-associated virus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Development and Optimization of AAV hFIX Particles by Transient Transfection in an iCELLis(®) Fixed-Bed Bioreactor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Primary recovery and chromatographic purification of adeno-associated virus type 2 produced by baculovirus/insect cell system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Identification of factors that contribute to recombinant AAV2 particle aggregation and methods to prevent its occurrence during vector purification and formulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Scalable downstream strategies for purification of recombinant adeno- associated virus vectors in light of the properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Separation of adeno-associated virus type 2 empty particles from genome containing vectors by anion-exchange column chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Scalable purification of adeno-associated virus serotype 1 (AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Analysis of particle content of recombinant adeno-associated virus serotype 8 vectors by ion-exchange chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

The interaction of heparin sulfate and adeno-associated virus 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

A single-step affinity column for purification of serotype-5 based adeno-associated viral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Purified influenza virus vaccine. A study of viral reactivity and antigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

CpG-depleted adeno-associated virus vectors evade immune detection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Good Manufacturing Practice Production of Self-Complementary Serotype 8 Adeno-Associated Viral Vector for a Hemophilia B Clinical Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Evidence for encapsidation of prokaryotic sequences during recombinant adeno-associated virus production and their in vivo persistence after vector delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Vector Characterization Methods for Quality Control Testing of Recombinant Adeno-Associated Viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Clearance and characterization of residual HSV DNA in recombinant adeno-associated virus produced by an HSV complementation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Production of recombinant adeno-associated viral vectors using a baculovirus/insect cell suspension culture system: from shake flasks to a 20-L bioreactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Evidence for packaging of rep-cap sequences into adeno-associated virus (AAV) type 2 capsids in the absence of inverted terminal repeats: a model for generation of rep-positive AAV particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Undetectable transcription of cap in a clinical AAV vector: implications for preformed capsid in immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Systemic Elimination ofde novoCapsid Protein Synthesis from Replication-Competent AAV Contamination in the Liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Adenovirus-associated virus vector-mediated gene transfer in hemophilia B

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

AAV empty capsids: for better or for worse?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Quantification of adeno-associated virus particles and empty capsids by optical density measurement

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Quantification of AAV particle titers by infrared fluorescence scanning of coomassie-stained sodium dodecyl sulfate-polyacrylamide gels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Systemic Errors in Quantitative Polymerase Chain Reaction Titration of Self-Complementary Adeno-Associated Viral Vectors and Improved Alternative Methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Evaluation of a droplet digital polymerase chain reaction format for DNA copy number quantification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Absolute determination of single-stranded and self-complementary adeno-associated viral vector genome titers by droplet digital PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Proteomics analysis of co-purifying cellular proteins associated with rAAV vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Manufacturing and characterizing AAV-based vectors for use in clinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

A pseudo-plaque method for infectious particle assay and clonal isolation of adeno-associated virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Infectious titer assay for adeno-associated virus vectors with sensitivity sufficient to detect single infectious events

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Fast and reliable titration of recombinant adeno-associated virus type-2 using quantitative real-time PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Development of a rapid, robust, and universal picogreen-based method to titer adeno-associated vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/BIOT.201600193

Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Electron cryo-microscopy and image reconstruction of adeno-associated virus type 2 empty capsids

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

A sensitive cell-based assay to measure the doxycycline concentration in biological samples.

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

A novel and rapid method to determine doxycycline in human plasma by liquid chromatography tandem mass spectrometry

21 January 2018

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Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system

21 January 2018

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Successful regional delivery and long-term expression of a dystrophin gene in canine muscular dystrophy: a preclinical model for human therapies

21 January 2018

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Induction of immune tolerance to FIX by intramuscular AAV gene transfer is independent of the activation status of dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Mycoplasma testing of cell substrates and biologics: Review of alternative non-microbiological techniques

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Endotoxin detection--from limulus amebocyte lysate to recombinant factor C.

21 January 2018

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https://api.crossref.org/works/10.1002/BIOT.201600193

Evidence for pH-dependent protease activity in the adeno-associated virus capsid

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIOT.201600193

1 reference

9 September 2017

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