Oncogenic signaling of MEK5-ERK5. (Q39116456)

29 June 2018

title

Oncogenic signaling of MEK5-ERK5. (English)

1 reference

29 June 2018

author name string

Van T Hoang

1

1 reference

29 June 2018

Thomas J Yan

2

1 reference

29 June 2018

Jane E Cavanaugh

3

1 reference

29 June 2018

Patrick T Flaherty

4

1 reference

29 June 2018

Barbara S Beckman

5

1 reference

29 June 2018

Matthew E Burow

6

1 reference

29 June 2018

language of work or name

English

0 references

publication date

30 January 2017

1 reference

29 June 2018

published in

Cancer Letters

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29 June 2018

volume

392

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29 June 2018

page(s)

51-59

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29 June 2018

Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis

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MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells.

30 June 2018

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Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells.

30 June 2018

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A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas

30 June 2018

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Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer

30 June 2018

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MEKK2 regulates focal adhesion stability and motility in invasive breast cancer cells.

30 June 2018

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Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis

30 June 2018

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Overexpression of MEKK2 is associated with colorectal carcinogenesis

30 June 2018

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MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis

30 June 2018

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ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma.

30 June 2018

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Potent antimyeloma activity of a novel ERK5/CDK inhibitor

30 June 2018

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30 June 2018

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Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex

30 June 2018

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Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor

30 June 2018

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30 June 2018

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Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

30 June 2018

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BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction

30 June 2018

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Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links

30 June 2018

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Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer

30 June 2018

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BMK1 kinase suppresses epithelial-mesenchymal transition through the Akt/GSK3β signaling pathway

30 June 2018

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Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), J

30 June 2018

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Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis

30 June 2018

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RNAi silencing of the MEKK3 gene promotes TRAIL-induced apoptosis in MCF-7 cells and suppresses the transcriptional activity of NF-κB

30 June 2018

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TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties

30 June 2018

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Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cells

30 June 2018

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Targeting the BMK1 MAP kinase pathway in cancer therapy.

30 June 2018

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ERK5 signalling in prostate cancer promotes an invasive phenotype

30 June 2018

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Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

30 June 2018

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MEKK3 expression correlates with nuclear factor kappa B activity and with expression of antiapoptotic genes in serous ovarian carcinoma

30 June 2018

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Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target

30 June 2018

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A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling

30 June 2018

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Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype

30 June 2018

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ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry

30 June 2018

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Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

30 June 2018

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Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC).

30 June 2018

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Activation of a C-terminal transcriptional activation domain of ERK5 by autophosphorylation.

30 June 2018

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Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cells

30 June 2018

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Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway

30 June 2018

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Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling

30 June 2018

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ERK5 activates NF-kappaB in leukemic T cells and is essential for their growth in vivo.

30 June 2018

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Neuroprotective role of ERK1/2 and ERK5 in a dopaminergic cell line under basal conditions and in response to oxidative stress.

30 June 2018

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MAPK signalling: ERK5 versus ERK1/2.

30 June 2018

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Matrix metalloproteinases and tumor metastasis

30 June 2018

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Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms.

30 June 2018

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Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer

30 June 2018

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A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway.

30 June 2018

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Dimerization through the catalytic domain is essential for MEKK2 activation.

30 June 2018

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The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling.

30 June 2018

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Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB.

30 June 2018

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Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

30 June 2018

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ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons

30 June 2018

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An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

30 June 2018

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Regulation of c-Fos and Fra-1 by the MEK5-ERK5 pathway

30 June 2018

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MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion

30 June 2018

1 reference

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Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray

30 June 2018

1 reference

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Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.

30 June 2018

1 reference

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Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2

30 June 2018

1 reference

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The essential role of MEKK3 in TNF-induced NF-kappaB activation

30 June 2018

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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

30 June 2018

1 reference

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BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons.

30 June 2018

1 reference

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Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

30 June 2018

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Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

30 June 2018

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BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

30 June 2018

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Isolation of MEK5 and differential expression of alternatively spliced forms

30 June 2018

1 reference

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BIX02189 inhibits TGF-β1-induced lung cancer cell metastasis by directly targeting TGF-β type I receptor

30 June 2018

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The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma.

21 August 2018

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MAPK7 and MAP2K4 as prognostic markers in osteosarcoma.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

Multifunctional role of Erk5 in multiple myeloma

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

Activation of cyclin D1 expression by the ERK5 cascade

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

Resistance to 5-fluorouracil.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5901897

Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28153789

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Systemic treatment of colorectal cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28153789

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CANLET.2017.01.034

1 reference

29 June 2018

PMC publication ID

5901897

1 reference

29 June 2018

PubMed publication ID

28153789

1 reference

29 June 2018