WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production (Q39088795)

9 September 2017

title

WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production (English)

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9 September 2017

3

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Anne-Marie Lefrançois-Martinez

9 September 2017

17

Jérôme Bertherat

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Anne-Marie Lefrançois-Martinez

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Isabelle Sahut-Barnola

13

Isabelle Sahut-Barnola

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Marie Batisse-Lignier

14

Marie Batisse-Lignier

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Sheerazed Boulkroun

Sheerazed Boulkroun

4

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Guillaume Assié

Guillaume Assié

15

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Maria-Christina Zennaro

Maria-Christina Zennaro

8

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Laurence Amar

Laurence Amar

6

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author name string

Annabel Berthon

1

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9 September 2017

Coralie Drelon

2

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9 September 2017

Frédérique Tissier

5

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9 September 2017

Benoît Samson-Couterie

7

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9 September 2017

Pierre-François Plouin

9

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9 September 2017

Seham Skah

10

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9 September 2017

Michelina Plateroti

11

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9 September 2017

Hervé Lefèbvre

12

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9 September 2017

Antoine Martinez

18

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9 September 2017

Pierre Val

19

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9 September 2017

publication date

1 October 2013

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9 September 2017

published in

Human Molecular Genetics

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9 September 2017

volume

23

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9 September 2017

issue

4

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9 September 2017

page(s)

889-905

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Trends in the prevalence of primary aldosteronism, aldosterone-producing adenomas, and surgically correctable aldosterone-dependent hypertension

9 September 2017

cites work

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Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronism

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Changes in the Perceived Epidemiology of Primary Hyperaldosteronism

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Outcomes of adrenalectomy in patients with unilateral primary aldosteronism: a review

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Efficacy and tolerance of spironolactone in essential hypertension

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Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism

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Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial

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Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis

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TASK channel deletion in mice causes primary hyperaldosteronism

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Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.

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The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line

21 January 2018

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Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells.

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K channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension

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Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors

21 January 2018

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Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

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Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.

21 January 2018

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Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter

21 January 2018

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Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.

21 January 2018

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Wnt/β-catenin signalling in adrenal physiology and tumour development

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

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Brachy-syndactyly caused by loss of Sfrp2 function

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Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion

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Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

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The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production

21 January 2018

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Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells.

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Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers.

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Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD).

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The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.

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Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling

21 January 2018

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The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

21 January 2018

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Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

21 January 2018

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Apc tumor suppressor gene is the "zonation-keeper" of mouse liver

21 January 2018

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Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

21 January 2018

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Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer

21 January 2018

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Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

21 January 2018

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miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells

21 January 2018

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miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop.

21 January 2018

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MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration

21 January 2018

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Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis.

21 January 2018

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Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex

21 January 2018

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Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production

21 January 2018

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Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cells

21 January 2018

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Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis

21 January 2018

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Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires beta-catenin

21 January 2018

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WNT signaling in ovarian follicle biology and tumorigenesis

21 January 2018

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WNT4 is required for normal ovarian follicle development and female fertility.

21 January 2018

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Conditional deletion of beta-catenin mediated by Amhr2cre in mice causes female infertility

21 January 2018

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Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77

21 January 2018

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Cross-talk between NR4A orphan nuclear receptors and β-catenin signaling pathway in osteoblasts

21 January 2018

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Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth

21 January 2018

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Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells

21 January 2018

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Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis

21 January 2018

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Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway

21 January 2018

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The flavonoid quercetin in disease prevention and therapy: Facts and fancies

21 January 2018

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Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats.

21 January 2018

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Therapeutic Potential of Quercetin to Decrease Blood Pressure: Review of Efficacy and Mechanisms

21 January 2018

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Targeting Wnt signaling: can we safely eradicate cancer stem cells?

21 January 2018

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Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models

21 January 2018

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Protocol for the fast chromatin immunoprecipitation (ChIP) method

21 January 2018

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Aldosterone-Producing Adenoma Formation in the Adrenal Cortex Involves Expression of Stem/Progenitor Cell Markers

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDT484

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9 September 2017

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