Extended-spectrum antiprotozoal bumped kinase inhibitors: A review (Q39075089)

28065755

8 September 2017

title

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review (English)

1 reference

8 September 2017

10

1 reference

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9 June 2020

A O Lau

11

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9 June 2020

Dustin J. Maly

13

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9 June 2020

author name string

Wesley C Van Voorhis

1

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9 June 2020

J Stone Doggett

2

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9 June 2020

Marilyn Parsons

3

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9 June 2020

Matthew A Hulverson

4

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9 June 2020

Ryan Choi

5

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9 June 2020

Samuel L M Arnold

6

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9 June 2020

Michael W Riggs

7

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9 June 2020

Andrew Hemphill

8

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9 June 2020

Daniel K Howe

9

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9 June 2020

Ethan A Merritt

12

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9 June 2020

Erkang Fan

14

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9 June 2020

Kayode K Ojo

15

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publication date

5 January 2017

1 reference

28065755

Experimental Parasitology

8 September 2017

published in

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9 June 2020

volume

180

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9 June 2020

page(s)

71-83

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Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.

9 June 2020

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Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

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30 August 2018

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Coinfection by Ixodes Tick-Borne Pathogens: Ecological, Epidemiological, and Clinical Consequences

30 August 2018

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Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1.

30 August 2018

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Molecular Cloning and Functional Expression of the Equine K Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium

30 August 2018

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In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum

30 August 2018

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Dose-dependent effects of experimental infection with the virulent Neospora caninum Nc-Spain7 isolate in a pregnant mouse model

30 August 2018

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30 August 2018

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A single mutation in the gatekeeper residue in TgMAPKL-1 restores the inhibitory effect of a bumped kinase inhibitor on the cell cycle

30 August 2018

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An update on Sarcocystis neurona infections in animals and equine protozoal myeloencephalitis (EPM)

30 August 2018

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Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor

30 August 2018

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A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity

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30 August 2018

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Neospora caninum infection as a cause of reproductive failure in a sheep flock

30 August 2018

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The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites

30 August 2018

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Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).

30 August 2018

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30 August 2018

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Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

30 August 2018

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A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

30 August 2018

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30 August 2018

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30 August 2018

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Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).

30 August 2018

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30 August 2018

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Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii

30 August 2018

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Comparison of glycopyrrolate and atropine in ameliorating the adverse effects of imidocarb dipropionate in horses

30 August 2018

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30 August 2018

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Efficacy of imidocarb dipropionate in eliminating Theileria equi from experimentally infected horses

30 August 2018

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Distinct signalling pathways control Toxoplasma egress and host-cell invasion

30 August 2018

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30 August 2018

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Re-emergence of the apicomplexan Theileria equi in the United States: elimination of persistent infection and transmission risk

30 August 2018

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Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.

30 August 2018

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30 August 2018

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Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

30 August 2018

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Antibody fusions reduce onset of experimental Cryptosporidium parvum infection in calves

30 August 2018

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Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

30 August 2018

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The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

30 August 2018

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Outbreak of equine piroplasmosis in Florida

30 August 2018

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Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity

30 August 2018

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Occurrence of Neospora caninum and Toxoplasma gondii infections in ovine and caprine abortions.

30 August 2018

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Diagnosis and treatment of Sarcocystis neurona–induced myositis in a free-ranging California sea lion

30 August 2018

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Equine Piroplasmosis Associated withAmblyomma cajennenseTicks, Texas, USA

30 August 2018

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Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination

30 August 2018

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Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

30 August 2018

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A protozoal-associated epizootic impacting marine wildlife: mass-mortality of southern sea otters (Enhydra lutris nereis) due to Sarcocystis neurona infection

30 August 2018

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Appropriate time for primaquine treatment to reduce Plasmodium falciparum transmission in hypoendemic areas

30 August 2018

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Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

30 August 2018

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Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

30 August 2018

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Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

30 August 2018

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Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

30 August 2018

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Through the "gatekeeper door": exploiting the active kinase conformation

30 August 2018

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Efficacy of ponazuril 15% oral paste as a treatment for equine protozoal myeloencephalitis.

30 August 2018

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The impact of malaria parasitism: from corpuscles to communities

30 August 2018

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Treatment of cryptosporidiosis.

30 August 2018

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A perspective on Theileria equi infections in donkeys.

30 August 2018

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Effect of intermittent oral administration of ponazuril on experimental Sarcocystis neurona infection of horses

30 August 2018

1 reference

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Repeated high dose imidocarb dipropionate treatment did not eliminate Babesia caballi from naturally infected horses as determined by PCR-reverse line blot hybridization.

30 August 2018

1 reference

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Epidemiology and control of neosporosis and Neospora caninum

30 August 2018

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Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa

30 August 2018

1 reference

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Genetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, Brazil

30 August 2018

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Outcome of treatment for congenital toxoplasmosis, 1981-2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis Study

30 August 2018

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Immune control of Babesia bovis infection

30 August 2018

1 reference

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(Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate

30 August 2018

1 reference

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A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases

30 August 2018

1 reference

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Clinical and clinicopathological changes in 6 healthy ponies following intramuscular administration of multiple doses of imidocarb dipropionate.

30 August 2018

1 reference

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Naturally acquired Plasmodium knowlesi malaria in human, Thailand

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Early detection of Toxoplasma infection by molecular monitoring of Toxoplasma gondii in peripheral blood samples after allogeneic stem cell transplantation.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

In-vivo therapeutic efficacy trial with artemisinin derivative, buparvaquone and imidocarb dipropionate against Babesia equi infection in donkeys

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Review of Neospora caninum and neosporosis in animals

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Sarcocystis neurona infections in sea otter (Enhydra lutris): evidence for natural infections with sarcocysts and transmission of infection to opossums (Didelphis virginiana).

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Sarcocystis neurona infections in raccoons (Procyon lotor): evidence for natural infection with sarcocysts, transmission of infection to opossums (Didelphis virginiana), and experimental induction of neurologic disease in raccoons

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Determination of whole blood cholinesterase in different animal species using specific substrates

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

The striped skunk (Mephitis mephitis) is an intermediate host for Sarcocystis neurona

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Dual Sarcocystis neurona and Toxoplasma gondii infection in a Northern sea otter from Washington state, USA.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Magic bullets for protein kinases

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

The nine-banded armadillo (Dasypus novemcinctus) is an intermediate host for Sarcocystis neurona

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

First isolation of Sarcocystis neurona from the South American opossum, Didelphis albiventris, from Brazil

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Toxoplasma gondii: from animals to humans

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

A chemical switch for inhibitor-sensitive alleles of any protein kinase

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Characterization and formulation of multiple epitope-specific neutralizing monoclonal antibodies for passive immunization against cryptosporidiosis

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Acquisition of inhibitor-sensitive protein kinases through protein design

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Meningoencephalitis due to a Sarcocystis neurona-like protozoan in Pacific harbor seals (Phoca vitulina richardsi).

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Design of allele-specific inhibitors to probe protein kinase signaling

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Identification of opossums (Didelphis virginiana) as the putative definitive host of Sarcocystis neurona.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Extracerebral toxoplasmosis in patients infected with HIV. A French National Survey.

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

The effect of multiple rapid passage on strains of Babesia divergens: a comparison of the clinical effects on juvenile and adult cattle of passaged and irradiated parasites

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Imidocarb and parvaquone in the treatment of piroplasmosis (Babesia equi) in equids

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Equine piroplasmosis: a review

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Toxoplasmosis of the central nervous system in the acquired immunodeficiency syndrome

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Encephalomyelitis associated with a Sarcocystis neurona-like organism in a sea otter

30 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5498274

Equine piroplasmosis (Babesia equi): therapeutic trials of imidocarb dihydrochloride in horses and donkeys

4 November 2018

1 reference

12 December 2020

Parasitic apicomplexans harbor a chlorophyll a-D1 complex, the potential target for therapeutic triazines

1 reference

12 December 2020

Structural basis for selective inhibition of Src family kinases by PP1

1 reference

12 December 2020

New therapeutic approaches for equine protozoal myeloencephalitis: pharmacokinetics of diclazuril sodium salts in horses

1 reference

12 December 2020

Control of Babesia equi parasitemia

1 reference

12 December 2020

Imidocarb residues in edible bovine tissues and in vitro assessment of imidocarb metabolism and cytotoxicity

1 reference

12 December 2020

Clinicopathological aspects of imidocarb dipropionate toxicity in horses

1 reference

12 December 2020

Equine protozoal myeloencephalitis

1 reference

12 December 2020

10.1016/J.EXPPARA.2017.01.001

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28065755 AND SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28065755 AND SRC:MED&resulttype=core&format=json

9 June 2020

28065755

1 reference