Immunoregulation by members of the TGFβ superfamily (Q39019244)

8 September 2017

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title

Immunoregulation by members of the TGFβ superfamily (English)

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8 September 2017

2

Peter Ten Dijke

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8 September 2017

WanJun Chen

1

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8 September 2017

publication date

1 November 2016

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Nature Reviews Immunology

8 September 2017

published in

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8 September 2017

volume

16

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8 September 2017

issue

12

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8 September 2017

page(s)

723-740

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Specificity and versatility in tgf-beta signaling through Smads

8 September 2017

cites work

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Matters of context guide future research in TGFβ superfamily signaling

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TGFβ signalling in context

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Non-Smad signaling pathways

31 March 2020

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https://api.crossref.org/works/10.1038/NRI.2016.112

TGF-beta and 'adaptive' Foxp3( ) regulatory T cells

31 March 2020

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Development of thymic Foxp3( ) regulatory T cells: TGF-β matters

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TGF-beta: the missing link in CD4 CD25 regulatory T cell-mediated immunosuppression

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The polarization of immune cells in the tumour environment by TGFbeta

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Transforming growth factor-beta in T-cell biology

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TGFbeta signalling in control of T-cell-mediated self-reactivity

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TGFβ in T cell biology and tumor immunity: Angel or devil?

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Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

31 March 2020

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Control of the development of CD8αα intestinal intraepithelial lymphocytes by TGF-β.

31 March 2020

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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

31 March 2020

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Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

31 March 2020

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A critical function for TGF-beta signaling in the development of natural CD4 CD25 Foxp3 regulatory T cells

31 March 2020

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https://api.crossref.org/works/10.1038/NRI.2016.112

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

31 March 2020

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

31 March 2020

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Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.

31 March 2020

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https://api.crossref.org/works/10.1038/NRI.2016.112

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

31 March 2020

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Role of activin A in the induction of Foxp3 and Foxp3- CD4 regulatory T cells.

31 March 2020

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31 March 2020

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The TGF-β superfamily in dendritic cell biology.

31 March 2020

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https://api.crossref.org/works/10.1038/NRI.2016.112

The canonical BMP signaling pathway is involved in human monocyte-derived dendritic cell maturation

31 March 2020

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https://api.crossref.org/works/10.1038/NRI.2016.112

The BMP Pathway Participates in Human Naive CD4 T Cell Activation and Homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Anti-inflammatory activity of bone morphogenetic protein signaling pathways in stomachs of mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

GARP regulates the bioavailability and activation of TGFβ.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

The activins and their binding protein, follistatin-Diagnostic and therapeutic targets in inflammatory disease and fibrosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Type IV collagens regulate BMP signalling in Drosophila

31 March 2020

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https://api.crossref.org/works/10.1038/NRI.2016.112

BMP signalling: agony and antagony in the family

31 March 2020

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https://api.crossref.org/works/10.1038/NRI.2016.112

The RGM/DRAGON family of BMP co-receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Negative regulation of TGF-beta receptor/Smad signal transduction.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

When versatility matters: activins/inhibins as key regulators of immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Follistatin modulates activin activity in a cell- and tissue-specific manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

1α,25-dihydroxyvitamin D3 stimulates activin A production to fine-tune osteoblast-induced mineralization.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Induced expression of the new cytokine, activin A, in human monocytes: inhibition by glucocorticoids and retinoic acid

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin A/erythroid differentiation factor is induced during human monocyte activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Differential responses of epithelial Sertoli cells of the rat testis to Toll-like receptor 2 and 4 ligands: implications for studies of testicular inflammation using bacterial lipopolysaccharides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Stimulatory effects of lipopolysaccharide on endothelial cell activin and follistatin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Serum activin-A as a predictive and prognostic marker in critically ill patients with sepsis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin in humoral immune responses.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin A as a mediator of NK-dendritic cell functional interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin-A attenuates several human natural killer cell functions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin-A: a novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Regulation of activin A expression in mast cells and asthma: its effect on the proliferation of human airway smooth muscle cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Calcium-regulated expression of activin A in RBL-2H3 mast cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Role of activin A in murine mast cells: modulation of cell growth, differentiation, and migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin A is an acute allergen-responsive cytokine and provides a link to TGF-beta-mediated airway remodeling in asthma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

A dual role of activin A in regulating immunoglobulin production of B cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Inhibins are the major activin ligands expressed during early thymocyte development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Transforming growth factor-beta- and Activin-Smad signaling pathways are activated at distinct maturation stages of the thymopoeisis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activins and inhibins: novel regulators of thymocyte development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin A and TGF-β promote T(H)9 cell-mediated pulmonary allergic pathology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin a promotes the TGF-beta-induced conversion of CD4 CD25- T cells into Foxp3 induced regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

TGF-β1 Dependent Generation of LAG Dendritic Cells from CD34 Progenitors in Serum-Free Medium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Role of TGFbeta in skin inflammation and carcinogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Effect of bone morphogenetic protein-6 on macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Bone morphogenetic protein-6 induces the expression of inducible nitric oxide synthase in macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Inhibition of BMP signaling suppresses metastasis in mammary cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Expression of BMPRIA on human thymic NK cell precursors: role of BMP signaling in intrathymic NK cell development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

A Tale from TGF-β Superfamily for Thymus Ontogeny and Function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

BMP signaling is required for normal thymus development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Interplay between BMP4 and IL-7 in human intrathymic precursor cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

The bright and the dark sides of activin in wound healing and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Mechanisms of action of bone morphogenetic proteins in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Beyond TGFβ: roles of other TGFβ superfamily members in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Autocrine activation of canonical BMP signaling regulates PD-L1 and PD-L2 expression in human dendritic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Synergistic effect of TGF-beta superfamily members on the induction of Foxp3 Treg

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

The immunoregulatory and fibrotic roles of activin A in allergic asthma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin A: a potential therapeutic target for characterizing and stopping joint pain early in rheumatoid arthritis patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

High Levels of Maternal Serum IL-17 and Activin A in Pregnant Women Affected by Systemic Lupus Erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

A novel 1,25-dihydroxyvitamin D-activin A pathway in human alveolar macrophages is dysfunctional in patients with pulmonary alveolar proteinosis (PAP).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Immunohistochemical study of arginase-1 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Identification of Acvr2a as a Th17 cell-specific gene induced during Th17 differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

TGF-β/BMPs: crucial crossroad in neural autoimmune disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Follistatin does not influence the course of Escherichia coli K1 sepsis in a mouse model.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Regulation of activin A synthesis in microglial cells: pathophysiological implications for bacterial meningitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Increased activin levels in cerebrospinal fluid of rabbits with bacterial meningitis are associated with activation of microglia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Commensal Bacteria-induced Interleukin 1β (IL-1β) Secreted by Macrophages Up-regulates Hepcidin Expression in Hepatocytes by Activating the Bone Morphogenetic Protein Signaling Pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

TGF-beta signaling is required for the function of insulin-reactive T regulatory cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

T cells that cannot respond to TGF-beta escape control by CD4( )CD25( ) regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

T-cell TGF-β signaling abrogation restricts medulloblastoma progression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Truncated form of TGF-βRII, but not its absence, induces memory CD8 T cell expansion and lymphoproliferative disorder in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Alternatively activated macrophages in protozoan infections

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Disruption of TGF-β signaling in T cells accelerates atherosclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Transforming growth factor-beta suppresses the activation of CD8 T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

The DNA-binding inhibitor Id3 regulates IL-9 production in CD4( ) T cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Cutting edge: Smad2 and Smad4 regulate TGF-β-mediated Il9 gene expression via EZH2 displacement

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Smad4 is critical for self-renewal of hematopoietic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Smad5 is dispensable for adult murine hematopoiesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Smad7 gene therapy ameliorates an autoimmune crescentic glomerulonephritis in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Involvement of twisted gastrulation in T cell-independent plasma cell production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Direct BMP2/4 signaling through BMP receptor IA regulates fetal thymocyte progenitor homeostasis and differentiation to CD4 CD8 double-positive cell

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Adult-specific systemic over-expression reveals novel in vivo effects of the soluble forms of ActRIIA, ActRIIB and BMPRII.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Selective targeting of TGF-β activation to treat fibroinflammatory airway disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Soluble betaglycan reduces renal damage progression in db/db mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Development of novel activin-targeted therapeutics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin-binding protein from rat ovary is follistatin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

The effects of an ActRIIb receptor Fc fusion protein ligand trap in juvenile simian immunodeficiency virus-infected rhesus macaques

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

PF-03446962, a fully-human monoclonal antibody against transforming growth-factor β (TGFβ) receptor ALK1, in pre-treated patients with urothelial cancer: an open label, single-group, phase 2 trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Augmented autocrine bone morphogenic protein (BMP) 7 signaling increases the metastatic potential of mouse breast cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

A new class of small molecule inhibitor of BMP signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRI.2016.112

The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair

31 March 2020

1 reference

12 December 2020

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin

1 reference

12 December 2020

Sotatercept, a soluble activin receptor type 2A IgG-Fc fusion protein for the treatment of anemia and bone loss

1 reference

12 December 2020

Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse.

1 reference

12 December 2020

Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms.

1 reference

12 December 2020

Potent induction of activin A secretion from monocytes and bone marrow stromal fibroblasts by cognate interaction with activated T cells.

1 reference

12 December 2020

Passive immunoneutralization with a monoclonal antibody reveals a role for endogenous activin-B in mediating FSH hypersecretion during estrus and following ovariectomy of hypophysectomized, pituitary-grafted rats

1 reference

12 December 2020

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

1 reference

12 December 2020

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1

1 reference

12 December 2020

Role of activin A in negative regulation of normal and tumor B lymphocytes

1 reference

12 December 2020

Production and function of activin A in human dendritic cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI.2016.112

1 reference

8 September 2017

1 reference