Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation (Q39010703)

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scientific article published on 12 February 2014

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English	Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation	scientific article published on 12 February 2014

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8 September 2017

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation (English)

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8 September 2017

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11 June 2020

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11 June 2020

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11 June 2020

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11 June 2020

Matthew J Sykes

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11 June 2020

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11 June 2020

Malika Kumarasiri

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Malika Kumarasiri

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11 June 2020

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Peng Li

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11 June 2020

Frankie Lam

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11 June 2020

Sunita K C Basnet

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11 June 2020

Shudong Wang

11

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11 June 2020

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12 February 2014

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8 September 2017

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11 June 2020

9

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11 June 2020

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11 June 2020

962-972

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11 June 2020

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1 reference

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In vivo efficacy of natural product-inspired irreversible kinase inhibitors

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Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment

1 reference

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Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site

1 reference

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21 January 2018

Insights into the Importance of DFD-Motif and Insertion I1 in Stabilizing the DFD-Out Conformation of Mnk2 Kinase

1 reference

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21 January 2018

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity

1 reference

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21 January 2018

Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents

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21 January 2018

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

1 reference

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21 January 2018

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Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest

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21 January 2018

Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation

1 reference

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Pharmacological targeting of eIF4E in primary CLL lymphocytes

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Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

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21 January 2018

Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases

1 reference

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7 January 2021

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