Upregulated SMAD3 promotes epithelial-mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma (Q39006829)

8 September 2017

title

Upregulated SMAD3 promotes epithelial-mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma (English)

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8 September 2017

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11

Michiie Sakamoto

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8 September 2017

5

Nobuyoshi Hiraoka

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8 September 2017

Ken Yamazaki

1

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8 September 2017

Yohei Masugi

2

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8 September 2017

Kathryn Effendi

3

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8 September 2017

Hanako Tsujikawa

4

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8 September 2017

Minoru Kitago

6

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8 September 2017

Masahiro Shinoda

7

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8 September 2017

Osamu Itano

8

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8 September 2017

Minoru Tanabe

9

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8 September 2017

Yuko Kitagawa

10

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8 September 2017

publication date

7 April 2014

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8 September 2017

published in

Laboratory Investigation

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8 September 2017

volume

94

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8 September 2017

issue

6

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8 September 2017

page(s)

683-691

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8 September 2017

cites work

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SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

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Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility

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Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.

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Smad-Sp1 complexes mediate TGFbeta-induced early transcription of oncogenic Smad7 in pancreatic cancer cells

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Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression

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Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation

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Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses

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Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells

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Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice

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Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer

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NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway

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The grade of pancreatic ductal carcinoma is an independent prognostic factor and is superior to the immunohistochemical assessment of proliferation.

21 January 2018

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12 December 2020

Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation

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12 December 2020

Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival

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12 December 2020

The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma

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12 December 2020

Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to e-cadherin expression

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12 December 2020

DPC4 gene in various tumor types

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12 December 2020

10.1038/LABINVEST.2014.53

Identifiers

DOI

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8 September 2017

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