The Relaxation Properties of Myofibrils Are Compromised by Amino Acids that Stabilize α-Tropomyosin (Q38999473)

20 May 2018

title

The Relaxation Properties of Myofibrils Are Compromised by Amino Acids that Stabilize α-Tropomyosin (English)

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20 May 2018

author name string

Beatrice Scellini

1

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20 May 2018

Nicoletta Piroddi

2

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20 May 2018

Alexander M Matyushenko

3

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20 May 2018

Dmitrii I Levitsky

4

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20 May 2018

Corrado Poggesi

5

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20 May 2018

Sherwin S Lehrer

6

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20 May 2018

Chiara Tesi

7

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20 May 2018

language of work or name

English

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publication date

1 January 2017

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20 May 2018

published in

Biophysical Journal

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20 May 2018

volume

112

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20 May 2018

issue

2

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20 May 2018

page(s)

376-387

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20 May 2018

Thin Filament Structure and the Steric Blocking Model

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Stabilizing the central part of tropomyosin increases the bending stiffness of the thin filament

17 June 2018

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Structure of the F-actin-tropomyosin complex

17 June 2018

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Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state

17 June 2018

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Stabilization of the Central Part of Tropomyosin Molecule Alters the Ca2 -sensitivity of Actin-Myosin Interaction

17 June 2018

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17 June 2018

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Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L

17 June 2018

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Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation

17 June 2018

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Long-Range Effects of Familial Hypertrophic Cardiomyopathy Mutations E180G and D175N on the Properties of Tropomyosin

17 June 2018

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Structural implications of conserved aspartate residues located in tropomyosin’s coiled-coil core

17 June 2018

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Tropomyosin: double helix from the protein world

17 June 2018

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Tropomyosin is in a reduced state in rabbit psoas muscle

17 June 2018

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Conserved noncanonical residue Gly-126 confers instability to the middle part of the tropomyosin molecule.

17 June 2018

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The C terminus of cardiac troponin I stabilizes the Ca2 -activated state of tropomyosin on actin filaments

17 June 2018

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Ca2 -dependent photocrosslinking of tropomyosin residue 146 to residues 157-163 in the C-terminal domain of troponin I in reconstituted skeletal muscle thin filaments

17 June 2018

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Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils

17 June 2018

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Gestalt-binding of tropomyosin to actin filaments.

17 June 2018

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Structural basis for the regulation of muscle contraction by troponin and tropomyosin

17 June 2018

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Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle

17 June 2018

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Sarcomeric determinants of striated muscle relaxation kinetics

17 June 2018

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Force kinetics and individual sarcomere dynamics in cardiac myofibrils after rapid ca(2 ) changes

17 June 2018

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Relaxation kinetics following sudden Ca(2 ) reduction in single myofibrils from skeletal muscle

17 June 2018

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Vertebrate tropomyosin: distribution, properties and function

17 June 2018

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The effect of inorganic phosphate on force generation in single myofibrils from rabbit skeletal muscle

17 June 2018

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Regulation of contraction in striated muscle

17 June 2018

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Active and passive forces of isolated myofibrils from cardiac and fast skeletal muscle of the frog

17 June 2018

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17 June 2018

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Functional alpha-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-terminal acetyl group

17 June 2018

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Effect of Ca2 on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction

17 June 2018

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Intramolecular crosslinking of tropomyosin via disulfide bond formation: evidence for chain register

17 June 2018

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Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation

17 June 2018

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α-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains

21 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5266141

Conserved Asp-137 imparts flexibility to tropomyosin and affects function

21 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5266141

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5266141

Characterization of the cross-bridge force-generating step using inorganic phosphate and BDM in myofibrils from rabbit skeletal muscles

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5266141

Correlation of ActoS1, myofibrillar, and muscle fiber ATPases.

21 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5266141

Impact of tropomyosin isoform composition on fast skeletal muscle thin filament regulation and force development

21 August 2018

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12 December 2020

Increased Ca2 affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I

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12 December 2020

Structural changes in myosin motors and filaments during relaxation of skeletal muscle

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12 December 2020

Regulation of the cross-bridge transition from a weakly to strongly bound state in skinned rabbit muscle fibers

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12 December 2020

Calcium dependence of the apparent rate of force generation in single striated muscle myofibrils activated by rapid solution changes

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12 December 2020

Extraction and Replacement of the Tropomyosin–Troponin Complex in Isolated Myofibrils

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12 December 2020

Structural and functional effects of two stabilizing substitutions, D137L and G126R, in the middle part of α-tropomyosin molecule

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12 December 2020

The influence of 2,3-butanedione 2-monoxime (BDM) on the interaction between actin and myosin in solution and in skinned muscle fibres

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12 December 2020

Smooth muscle alpha-tropomyosin crosslinks to caldesmon, to actin and to myosin subfragment 1 on the muscle thin filament

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12 December 2020

Kinetics of adenosine triphosphate hydrolysis by shortening myofibrils from rabbit psoas muscle

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12 December 2020

C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning

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12 December 2020

Effects of two stabilizing substitutions, D137L and G126R, in the middle part of α-tropomyosin on the domain structure of its molecule

1 reference

12 December 2020

10.1016/J.BPJ.2016.12.013

Identifiers

DOI

1 reference

20 May 2018

PMC publication ID

5266141

1 reference

20 May 2018

PubMed publication ID

28122223

1 reference

20 May 2018