4-amino bis-pyridinium derivatives as novel antileishmanial agents. (Q38998325)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24798287 AND SRC:MED&resulttype=core&format=json

17 March 2020

title

4-amino bis-pyridinium derivatives as novel antileishmanial agents (English)

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17 March 2020

2

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17 March 2020

Santiago Castanys

4

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17 March 2020

Francisco Gamarro

6

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17 March 2020

author name string

Verónica Gómez-Pérez

1

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17 March 2020

Raquel García-Hernández

3

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17 March 2020

Joaquín M Campos Rosa

5

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17 March 2020

language of work or name

English

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publication date

5 May 2014

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Antimicrobial Agents and Chemotherapy

17 March 2020

published in

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17 March 2020

volume

58

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17 March 2020

issue

7

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17 March 2020

page(s)

4103-4112

1 reference

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Cellular growth and mitochondrial ultrastructure of leishmania (Viannia) braziliensis promastigotes are affected by the iron chelator 2,2-dipyridyl

17 March 2020

cites work

1 reference

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A new ABC half-transporter in Leishmania major is involved in resistance to antimony.

9 September 2017

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A novel Leishmania major amastigote assay in 96-well format for rapid drug screening and its use for discovery and evaluation of a new class of leishmanicidal quinolinium salts

9 September 2017

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Choline analogues in malaria chemotherapy

9 September 2017

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Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania

9 September 2017

1 reference

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The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase

9 September 2017

1 reference

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Symmetrical choline-derived dications display strong anti-kinetoplastid activity

9 September 2017

1 reference

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Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation

9 September 2017

1 reference

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Cell death by necrosis: towards a molecular definition

9 September 2017

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Mitochondrial H( ) leak and ROS generation: an odd couple

9 September 2017

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The use of lead citrate at high pH as an electron-opaque stain in electron microscopy

9 September 2017

1 reference

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Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.

9 September 2017

1 reference

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Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation

9 September 2017

1 reference

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Role of free radicals and catalytic metal ions in human disease: an overview

9 September 2017

1 reference

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The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei

9 September 2017

1 reference

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Novel 4-amino bis-pyridinium and bis-quinolinium derivatives as choline kinase inhibitors with antiproliferative activity against the human breast cancer SKBR-3 cell line

9 September 2017

1 reference

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Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Antileishmanial activities of several classes of aromatic dications

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Modulation of gene expression in human macrophages treated with the anti-leishmania pentavalent antimonial drug sodium stibogluconate.

14 September 2017

1 reference

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Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major

14 September 2017

1 reference

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Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Putrescine and spermidine transport in Leishmania.

17 June 2018

1 reference

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Ca2 transport by digitonin-permeabilized Leishmania donovani. Effects of Ca2 , pentamidine and WR-6026 on mitochondrial membrane potential in situ

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Detection and characterization of Leishmania species and strains from mammals and vectors by hybridization and restriction endonuclease digestion of kinetoplast DNA.

17 June 2018

1 reference

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Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

17 June 2018

1 reference

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Inhibition by Dications of in vitro growth of Leishmania major and Leishmania tropica: causative agents of old world cutaneous leishmaniasis

21 August 2018

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Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania

21 August 2018

1 reference

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Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani.

21 August 2018

2 references

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21 August 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani

2 December 2018

1 reference

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Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: complex II inhibition results in increased pentamidine cytotoxicity.

21 August 2018

1 reference

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Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Increase in cytosolic Ca2 levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis-like death in Leishmania donovani promastigotes

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068582

Several lines of evidence demonstrating that Plasmodium falciparum, a parasitic organism, has distinct enzymes for the phosphorylation of choline and ethanolamine

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24798287

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Use of the green fluorescent protein as a marker in transfected Leishmania

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24798287

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mitochondrial superoxide mediates heat-induced apoptotic-like death in Leishmania infantum

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24798287

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.02481-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24798287 AND SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24798287 AND SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

24798287

1 reference