ROS-mediated EB1 phosphorylation through Akt/GSK3β pathway: implication in cancer cell response to microtubule-targeting agents. (Q38984621)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930764 AND SRC:MED&resulttype=core&format=json

20 March 2020

title

ROS-mediated EB1 phosphorylation through Akt/GSK3β pathway: implication in cancer cell response to microtubule-targeting agents (English)

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20 March 2020

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2

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20 March 2020

author name string

Marion Le Grand

1

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20 March 2020

Veronique Bourgarel-Rey

3

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20 March 2020

Stephane Honore

4

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20 March 2020

Sonia Bastonero

5

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20 March 2020

Diane Braguer

6

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20 March 2020

Manon Carre

7

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20 March 2020

language of work or name

English

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publication date

1 May 2014

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20 March 2020

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20 March 2020

volume

5

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20 March 2020

issue

10

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20 March 2020

page(s)

3408-3423

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EB1 accelerates two conformational transitions important for microtubule maturation and dynamics.

20 March 2020

cites work

1 reference

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Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma.

9 September 2017

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Glycogen synthase kinase-3 (GSK3) controls deoxyglucose-induced mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells

9 September 2017

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Anti-migratory effect of vinflunine in endothelial and glioblastoma cells is associated with changes in EB1 C-terminal detyrosinated/tyrosinated status

9 September 2017

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Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis

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End-binding proteins sensitize microtubules to the action of microtubule-targeting agents

9 September 2017

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9 September 2017

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Physical confinement alters tumor cell adhesion and migration phenotypes.

9 September 2017

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EBs Recognize a Nucleotide-Dependent Structural Cap at Growing Microtubule Ends

9 September 2017

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Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo

9 September 2017

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EB1 is required for spindle symmetry in mammalian mitosis

9 September 2017

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Targeting Mitochondria in Fighting Cancer

9 September 2017

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Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

9 September 2017

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Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species

9 September 2017

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Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission–fusion proteins

9 September 2017

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Microtubule-targeted agents: when mitochondria become essential to chemotherapy

9 September 2017

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Microtubule-binding agents: a dynamic field of cancer therapeutics

9 September 2017

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Microtubule tip-interacting proteins: a view from both ends

9 September 2017

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Redox Regulation of the Intrinsic Pathway in Neuronal Apoptosis

9 September 2017

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Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells.

9 September 2017

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Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium

9 September 2017

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Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

9 September 2017

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APC in cell migration

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PI-3-K and AKT: Onto the mitochondria

9 September 2017

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Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

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9 September 2017

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Tracking the ends: a dynamic protein network controls the fate of microtubule tips

9 September 2017

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9 September 2017

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9 September 2017

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

9 September 2017

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9 September 2017

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Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway

9 September 2017

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The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules

9 September 2017

1 reference

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EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules

9 September 2017

1 reference

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Cellular response to oxidative stress: signaling for suicide and survival

9 September 2017

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Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation

9 September 2017

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Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells'

9 September 2017

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

9 September 2017

1 reference

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MK-2206, an Akt inhibitor, enhances carboplatinum/paclitaxel efficacy in gastric cancer cell lines

9 September 2017

1 reference

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The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer.

9 September 2017

1 reference

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Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends

9 September 2017

1 reference

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Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity

9 September 2017

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Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition

9 September 2017

1 reference

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Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia.

9 September 2017

1 reference

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VE-cadherin signaling induces EB3 phosphorylation to suppress microtubule growth and assemble adherens junctions

14 September 2017

1 reference

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NVP-BEZ235 as a new therapeutic option for sarcomas.

14 September 2017

1 reference

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Migration and actin protrusion in melanoma cells are regulated by EB1 protein

14 September 2017

1 reference

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Antiangiogenic vinflunine affects EB1 localization and microtubule targeting to adhesion sites.

14 September 2017

1 reference

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Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria

14 September 2017

1 reference

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Inhibiting the akt pathway in cancer treatment: three leading candidates

14 September 2017

1 reference

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Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases.

17 June 2018

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Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used.

17 June 2018

1 reference

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A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules

17 June 2018

1 reference

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AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.

21 August 2018

1 reference

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Oncogenic function of microtubule end-binding protein 1 in breast cancer

21 August 2018

1 reference

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Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis.

21 August 2018

1 reference

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Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway

21 August 2018

1 reference

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Direct effect of Taxol on free radical formation and mitochondrial permeability transition

21 August 2018

1 reference

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Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine

21 August 2018

1 reference

12 December 2020

AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation

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12 December 2020

Mitochondria-specific nanocarriers for improving the proapoptotic activity of small molecules

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12 December 2020

Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells

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12 December 2020

Identifiers

DOI

10.18632/ONCOTARGET.1982

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930764 AND SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930764 AND SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

24930764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24930764 AND SRC:MED&resulttype=core&format=json