Approaches for targeting cancer stem cells drug resistance (Q38971795)

8 September 2017

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title

Approaches for targeting cancer stem cells drug resistance (English)

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8 September 2017

main subject

neoplastic stem cells

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Roberta Rosa

1

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8 September 2017

Valentina D'Amato

series ordinal

2

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8 September 2017

Sabino De Placido

series ordinal

3

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8 September 2017

Roberto Bianco

series ordinal

4

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8 September 2017

language of work or name

English

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publication date

4 October 2016

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Expert Opinion on Drug Discovery

8 September 2017

published in

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8 September 2017

volume

11

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8 September 2017

issue

12

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8 September 2017

page(s)

1201-1212

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Stem cells, cancer, and cancer stem cells

8 September 2017

cites work

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The developing cancer stem-cell model: clinical challenges and opportunities

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Cells of origin in cancer

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Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma

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Epigenetic targeting of ovarian cancer stem cells

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Cavity-free plasmonic nanolasing enabled by dispersionless stopped light

21 January 2018

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The epithelial-mesenchymal transition generates cells with properties of stem cells

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

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Tackling the cancer stem cells - what challenges do they pose?

21 January 2018

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Normal stem cells and cancer stem cells: similar and different

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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

21 January 2018

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Analysis of gene expression and chemoresistance of CD133 cancer stem cells in glioblastoma

21 January 2018

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CD133 cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist

21 January 2018

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Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs

21 January 2018

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Regulation of EMT by Notch signaling pathway in tumor progression

21 January 2018

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CYLD regulates keratinocyte differentiation and skin cancer progression in humans.

21 January 2018

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Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells

21 January 2018

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Twist1 and Snail link Hedgehog signaling to tumor-initiating cell-like properties and acquired chemoresistance independently of ABC transporters

21 January 2018

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Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

21 January 2018

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Measurement of interaction between antiprotons

21 January 2018

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Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance

21 January 2018

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Targeting microRNAs in epithelial-to-mesenchymal transition-induced cancer stem cells: therapeutic approaches in cancer

21 January 2018

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MiR-124 Radiosensitizes human colorectal cancer cells by targeting PRRX1

21 January 2018

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Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

21 January 2018

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MiR-200c suppresses TGF-β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer

21 January 2018

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TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.

21 January 2018

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Brief report: The lincRNA Hotair is required for epithelial-to-mesenchymal transition and stemness maintenance of cancer cell lines

21 January 2018

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Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

An Epigenetic Reprogramming Strategy to Resensitize Radioresistant Prostate Cancer Cells.

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Cancer stem cells and immunoresistance: clinical implications and solutions

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Cancer stem cells: a metastasizing menace!

21 January 2018

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Src and focal adhesion kinase as therapeutic targets in cancer

21 January 2018

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Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients

21 January 2018

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A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors

21 January 2018

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Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship

21 January 2018

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Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting

21 January 2018

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CD73 is associated with poor prognosis in high-grade serous ovarian cancer

21 January 2018

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PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells.

21 January 2018

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Targeting RAS-ERK signalling in cancer: promises and challenges

21 January 2018

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Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer

21 January 2018

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ERK1/2 Regulation of CD44 Modulates Oral Cancer Aggressiveness

21 January 2018

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EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential

21 January 2018

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A randomized phase II presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast

21 January 2018

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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

21 January 2018

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Revisiting STAT3 signalling in cancer: new and unexpected biological functions

21 January 2018

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Suppression of cancer relapse and metastasis by inhibiting cancer stemness

21 January 2018

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Filtering promiscuous compounds in early drug discovery: is it a good idea?

21 January 2018

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Emerging role of nanog in tumorigenesis and cancer stem cells

21 January 2018

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Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells

21 January 2018

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Kinome profiling in pediatric brain tumors as a new approach for target discovery

21 January 2018

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

21 January 2018

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Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Can we safely target the WNT pathway?

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Arsenic trioxide induces differentiation of CD133 hepatocellular carcinoma cells and prolongs posthepatectomy survival by targeting GLI1 expression in a mouse model

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Wnt4 inhibits cell motility induced by oncogenic Ras

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

WNT signalling pathways as therapeutic targets in cancer

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Wnt Signaling in Cancer Stem Cell Biology

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Dysregulation of Wnt/β-Catenin Signaling in Gastrointestinal Cancers

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Cellular signaling and biological functions of R-spondins

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/17460441.2016.1243525

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Therapeutic modulation of Notch signalling--are we there yet?

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells.

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

A phase I dose escalation and expansion study of the anticancer stem cell agent demcizumab (anti-DLL4) in patients with previously treated solid tumors.

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas.

21 January 2018

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The sonic hedgehog signaling network in development and neoplasia

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Efficacy and safety of vismodegib in advanced basal-cell carcinoma.

21 January 2018

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Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

TGF-β/TGF-β receptor system and its role in physiological and pathological conditions.

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Metastasis: from dissemination to organ-specific colonization

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Insulin, estrogen, inflammatory markers, and risk of benign proliferative breast disease

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor-beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Clusterin mediates TGF-β-induced epithelial-mesenchymal transition and metastasis via Twist1 in prostate cancer cells

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis.

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Immune responses to human cancer stem-like cells/cancer-initiating cells

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Epitope landscape in breast and colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

MCF7 side population cells with characteristics of cancer stem/progenitor cells express the tumor antigen MUC1.

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Cancer/testis antigens can be immunological targets in clonogenic CD133 melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/17460441.2016.1243525

MUC1 immunobiology: from discovery to clinical applications

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

The blockade of immune checkpoints in cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/17460441.2016.1243525

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

21 January 2018

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https://api.crossref.org/works/10.1080/17460441.2016.1243525

Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/17460441.2016.1243525

Phase II randomized trial comparing sequential first-line everolimus and second-line sunitinib versus first-line sunitinib and second-line everolimus in patients with metastatic renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/17460441.2016.1243525

Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/17460441.2016.1243525

Sipuleucel-T immunotherapy for castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/17460441.2016.1243525

Mutational heterogeneity in cancer and the search for new cancer-associated genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/17460441.2016.1243525

Expression of stem cell and epithelial-mesenchymal transition markers in circulating tumor cells of breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/17460441.2016.1243525

10.1080/17460441.2016.1243525

21 January 2018

Identifiers

DOI

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8 September 2017

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