Precision medicine from the renal cancer genome (Q38970282)

8 September 2017

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title

Precision medicine from the renal cancer genome (English)

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8 September 2017

2

Mark Lathrop

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8 September 2017

Yasser Riazalhosseini

series ordinal

1

object named as

Yasser Riazalhosseini

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8 September 2017

language of work or name

English

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publication date

3 October 2016

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Nature Reviews Nephrology

8 September 2017

published in

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8 September 2017

volume

12

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8 September 2017

issue

11

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8 September 2017

page(s)

655-666

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Epidemiology and risk factors for kidney cancer

8 September 2017

cites work

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Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict

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Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity

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Renal cell carcinoma: current status and future prospects

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The epidemiology of bladder and kidney cancer

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Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

21 January 2018

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Comprehensive genomic characterization of head and neck squamous cell carcinomas

21 January 2018

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Genomic Classification of Cutaneous Melanoma

21 January 2018

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New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease

21 January 2018

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International renal-cell-cancer study. VI. the role of medical and family history

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Hereditary kidney cancer syndromes

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Fifteen-year quest for microphthalmia-associated transcription factor target genes

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

A germline mutation in PBRM1 predisposes to renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma.

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Germline BAP1 mutations predispose to renal cell carcinomas

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Variation in genomic landscape of clear cell renal cell carcinoma across Europe

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Comprehensive molecular characterization of clear cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Identification of the von Hippel-Lindau disease tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Mutations of the VHL tumour suppressor gene in renal carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

VHL, the story of a tumour suppressor gene

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Hypoxia--a key regulatory factor in tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Integrated molecular analysis of clear-cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

BAF180 promotes cohesion and prevents genome instability and aneuploidy

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Sleeping giants: emerging roles for the fat cadherins in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Cytoreductive nephrectomy for kidney cancer with sarcomatoid histology--is up-front resection indicated and, if not, is it avoidable?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Impact of pathological tumour characteristics in patients with sarcomatoid renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Genomic Characterization of Renal Cell Carcinoma with Sarcomatoid Dedifferentiation Pinpoints Recurrent Genomic Alterations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Novel mutations of the MET proto-oncogene in papillary renal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Inherited susceptibility to uterine leiomyomas and renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

MET is a potential target across all papillary renal cell carcinomas: result from a large molecular study of pRCC with CGH array and matching gene expression array

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

2009 update on the classification of renal epithelial tumors in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dubé-associated renal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

The somatic genomic landscape of chromophobe renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Oncotargets in different renal cancer subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Update on targeted therapies for clear cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Pazopanib versus sunitinib in metastatic renal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

mTOR inhibitors in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Molecular genetics of clear-cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Aristolochic acid exposure in Romania and implications for renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Signatures of mutational processes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Mechanisms underlying mutational signatures in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Loss of PBRM1 expression is associated with renal cell carcinoma progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Polybromo-1 (PBRM1), a SWI/SNF complex subunit is a prognostic marker in clear cell renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

A 16-gene assay to predict recurrence after surgery in localised renal cell carcinoma: development and validation studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Single nucleotide polymorphisms and risk of recurrence of renal-cell carcinoma: a cohort study

21 January 2018

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https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Intratumour heterogeneity in urologic cancers: from molecular evidence to clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

A river model to map convergent cancer evolution and guide therapy in RCC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Analyses of potential predictive markers and survival data for a response to sunitinib in patients with metastatic renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Prospective study assessing hypoxia-related proteins as markers for the outcome of treatment with sunitinib in advanced clear-cell renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

IL8 polymorphisms and overall survival in pazopanib- or sunitinib-treated patients with renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Renal-Cell Cancer--Targeting an Immune Checkpoint or Multiple Kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Genetic basis for clinical response to CTLA-4 blockade in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Intratumor heterogeneity: seeing the wood for the trees.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEPH.2016.133

A population--based case--control study of renal cell carcinoma

31 March 2020

1 reference

12 December 2020

Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma

1 reference

12 December 2020

Obesity and renal cell cancer--a quantitative review

1 reference

12 December 2020

Hereditary papillary renal cell carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRNEPH.2016.133

1 reference

8 September 2017

1 reference