Non-cytochrome P450-mediated bioactivation and its toxicological relevance. (Q38929936)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27533622 AND SRC:MED&resulttype=core&format=json

21 March 2020

review article

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title

Non-cytochrome P450-mediated bioactivation and its toxicological relevance (English)

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21 March 2020

1

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21 March 2020

author name string

Shuguang Ma

series ordinal

2

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21 March 2020

Donglu Zhang

series ordinal

3

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21 March 2020

language of work or name

English

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publication date

20 September 2016

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21 March 2020

published in

Drug Metabolism Reviews

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21 March 2020

volume

48

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issue

4

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21 March 2020

page(s)

473-501

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The proximate carcinogen trans-3,4-dihydroxy-3,4-dihydro-dibenz[c,h]acridine is oxidized stereoselectively and regioselectively by cytochrome 1A1, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats

21 March 2020

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Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition

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Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats

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ANIT-induced disruption of biliary function in rat hepatocyte couplets

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Genetic determinants of dabigatran plasma levels and their relation to bleeding

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Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

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Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen.

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Felbamate in epilepsy therapy: evaluating the risks

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Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism

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Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis.

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Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

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Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol

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Acyl glucuronides: the good, the bad and the ugly.

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N-deacetyl ketoconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Inhibitors of fatty acid oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

12-OH-nevirapine sulfate, formed in the skin, is responsible for nevirapine-induced skin rash

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Cathepsin B cleavable novel prodrug Ac-Phe-Lys-PABC-ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis: an experimental study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Bioactivation of the human carcinogen aristolochic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Identification of modified atropaldehyde mercapturic acids in rat and human urine after felbamate administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Bioactivation of MPTP: reactive metabolites and possible biochemical sequelae

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

N-chlorination of phenytoin by myeloperoxidase to a reactive metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Glutathione-conjugated toluene diisocyanate causes airway inflammation in sensitised mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Glutathione conjugation as a bioactivation reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Bioactivation of drugs: risk and drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Idiosyncratic toxicity: the role of toxicophores and bioactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Drug bioactivation, covalent binding to target proteins and toxicity relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Monitoring abacavir bioactivation in humans: screening for an aldehyde metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/03602532.2016.1225756

10.1080/03602532.2016.1225756

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27533622 AND SRC:MED&resulttype=core&format=json

21 March 2020

1 reference