Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol. (Q38924086)

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26 February 2020

title

Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol (English)

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26 February 2020

9

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author name string

Eric R Goedken

1

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26 February 2020

Maria A Argiriadi

2

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26 February 2020

David L Banach

3

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26 February 2020

Bryan A Fiamengo

4

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26 February 2020

Sage E Foley

5

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26 February 2020

Kristine E Frank

6

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26 February 2020

Jonathan S George

7

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Christopher M Harris

8

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26 February 2020

David C Ihle

10

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26 February 2020

Douglas Marcotte

11

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26 February 2020

Philip J Merta

12

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Mark E Michalak

13

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Sara E Murdock

14

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Medha J Tomlinson

15

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Jeffrey W Voss

16

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26 February 2020

language of work or name

English

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publication date

31 December 2014

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Journal of Biological Chemistry

26 February 2020

published in

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26 February 2020

volume

290

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26 February 2020

issue

8

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26 February 2020

page(s)

4573-4589

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Docking covalent inhibitors: a parameter free approach to pose prediction and scoring.

26 February 2020

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9 September 2017

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9 September 2017

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14 September 2017

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17 June 2018

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22 August 2018

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22 August 2018

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22 August 2018

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22 August 2018

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22 August 2018

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22 August 2018

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Crossref

https://api.crossref.org/works/10.1074/JBC.M114.595181

JAK2, a third member of the JAK family of protein tyrosine kinases

21 January 2018

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12 December 2020

The minimum significant ratio: a statistical parameter to characterize the reproducibility of potency estimates from concentration-response assays and estimation by replicate-experiment studies

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12 December 2020

Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3

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12 December 2020

Phase IIb dose‐ranging study of the oral JAK inhibitor tofacitinib (CP‐690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease‐modifying antirheumatic drugs

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12 December 2020

A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone

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Identifiers

DOI

10.1074/JBC.M114.595181

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25552479 AND SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25552479 AND SRC:MED&resulttype=core&format=json

26 February 2020

PubMed publication ID

25552479

1 reference